The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential
Abstract
The chorio-allantoic placenta forms through the fusion of the allantois(progenitor tissue of the umbilical cord), with the chorionic plate. The murine placenta contains high levels of hematopoietic stem cells, and is therefore a stem cell niche. However, it is not known whether the placenta is a site of hematopoietic cell emergence, or whether hematopoietic cells originate from other sites in the conceptus and then colonize the placenta. Here, we show that the allantois and chorion, isolated prior to the establishment of circulation, have the potential to give rise to myeloid and definitive erythroid cells following explant culture. We further show that the hematopoietic potential of the allantois and chorion does not require their union, indicating that it is an intrinsic property of these tissues. These results suggest that the placenta is not only a niche for, but also a source of, hematopoietic cells.
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Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., & Speck, N. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3444 · Cited by 1,178
Self-citationCbfa2 is required for the formation of intra-aortic hematopoietic clusters
North, T., Gu, T.-L., Stacy, T., Wang, Q., Howard, L., Binder, M., Marín-Padilla, M., & Speck, N. A. (1999) · Development · doi:10.1242/dev.126.11.2563 · Cited by 662
Self-citationMukouyama, Y.-S., Chiba, N., Hara, T., Okada, H., Ito, Y., Kanamaru, R., Miyajima, A., Satake, M., & Watanabe, T. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9617 · Cited by 81
Cited by
Of lineage and legacy: the development of mammalian hematopoietic stem cells
Dzierzak, E., & Speck, N. A. (2008) · Nature Immunology · doi:10.1038/ni1560 · Cited by 707
Self-citationEmbryonic origin of the adult hematopoietic system: advances and questions
Medvinsky, A., Rybtsov, S., & Taoudi, S. (2011) · Development · doi:10.1242/dev.040998 · Cited by 403
Resolving early mesoderm diversification through single-cell expression profiling
Scialdone, A., Tanaka, Y., Jawaid, W., Moignard, V., Wilson, N. K., Macaulay, I. C., Marioni, J. C., & Göttgens, B. (2016) · Nature · doi:10.1038/nature18633 · Cited by 293
RUNX transcription factors: orchestrators of development
Mevel, R., Draper, J. E., Lie-a-Ling, M., Kouskoff, V., & Lacaud, G. (2019) · Development · doi:10.1242/dev.148296 · Cited by 211
Scl Represses Cardiomyogenesis in Prospective Hemogenic Endothelium and Endocardium
Van Handel, B., Montel-Hagen, A., Sasidharan, R., Nakano, H., Ferrari, R., Boogerd, C. J., Schredelseker, J., Wang, Y., Hunter, S., Org, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.026 · Cited by 154
Metadata
- Authors
- Zeigler, B. M., Sugiyama, D., Chen, M., Guo, Y., Downs, K. M., & Speck, N. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-11-01
- Volume
- 133
- Issue
- 21
- Pages
- 4183-4192
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2089249520
- Cited by
- 178
- References
- 3
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zeigler, B. M., Sugiyama, D., Chen, M., Guo, Y., Downs, K. M., & Speck, N. A. (2006). The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential. Development. https://doi.org/10.1242/dev.02596
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