The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Gene regulatory networks underlying the compartmentalization of the Ciona central nervous system
Abstract
The tripartite organization of the central nervous system (CNS) may be an ancient character of the bilaterians. However, the elaboration of the more complex vertebrate brain depends on the midbrain-hindbrain boundary (MHB)organizer, which is absent in invertebrates such as Drosophila. The Fgf8 signaling molecule expressed in the MHB organizer plays a key role in delineating separate mesencephalon and metencephalon compartments in the vertebrate CNS. Here, we present evidence that an Fgf8 ortholog establishes sequential patterns of regulatory gene expression in the developing posterior sensory vesicle, and the interleaved `neck' region located between the sensory vesicle and visceral ganglion of the simple chordate Ciona intestinalis. The detailed characterization of gene networks in the developing CNS led to new insights into the mechanisms by which Fgf8/17/18 patterns the chordate brain. The precise positioning of this Fgf signaling activity depends on an unusual AND/OR network motif that regulates Snail, which encodes a threshold repressor of Fgf8expression. Nodal is sufficient to activate low levels of the Snail repressor within the neural plate, while the combination of Nodal and Neurogenin produces high levels of Snailin neighboring domains of the CNS. The loss of Fgf8 patterning activity results in the transformation of hindbrain structures into an expanded mesencephalon in both ascidians and vertebrates, suggesting that the primitive MHB-like activity predates the vertebrate CNS.
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“Conversely, the bGRN indirectly controls NN activity via setting the production levels of neurotransmitter receptors, ion channels, axon outgrowths, dendritic arborizations, and other physico-chemical components of the NN (49–52).”
From Behavior-related gene regulatory networks: A new level of organization in the brain (2020) · cites this paper as [50]
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The Draft Genome of Ciona intestinalis : Insights into Chordate and Vertebrate Origins
Dehal, P., Satou, Y., Campbell, R. K., Chapman, J., Degnan, B., De Tomaso, A., Davidson, B., Di Gregorio, A., Gelpke, M., Goodstein, D. M., et al. (2002) · Science · doi:10.1126/science.1080049 · Cited by 1,641 · cited 2×
“Moreover, Gbx is not present in the Ciona genome (Dehal et al., 2002; Wada et al., 2003).”
BackgroundSelf-citationNeural plate patterning: Upstream and downstream of the isthmic organizer
Wurst, W., & Bally-Cuif, L. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053516 · Cited by 575
Anteroposterior patterning in hemichordates and the origins of the chordate nervous system
Lowe, C. J., Wu, M., Salic, A., Evans, L., Lander, E., Stange-Thomann, N., Gruber, C. E., Gerhart, J., & Kirschner, M. (2003) · Cell · doi:10.1016/s0092-8674(03)00469-0 · Cited by 531
Corbo, J. C., Levine, M., & Zeller, R. W. (1997) · Development · doi:10.1242/dev.124.3.589 · Cited by 470
Self-citationRetinoid signalling in the development of the central nervous system
Maden, M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn963 · Cited by 428
Imai, K. S., Hino, K., Yagi, K., Satoh, N., & Satou, Y. (2004) · Development · doi:10.1242/dev.01270 · Cited by 418
Self-citationRegulatory Blueprint for a Chordate Embryo
Imai, K. S., Levine, M., Satoh, N., & Satou, Y. (2006) · Science · doi:10.1126/science.1123404 · Cited by 393
Self-citationChi, C. L., Martinez, S., Wurst, W., & Martin, G. R. (2003) · Development · doi:10.1242/dev.00487 · Cited by 343
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Self-citationWada, H., Saiga, H., Satoh, N., & Holland, P. W. H. (1998) · Development · doi:10.1242/dev.125.6.1113 · Cited by 312
Research works printed but not linked: 1
- 2002, Mech. Dev., 119, S275
Cited by
Ancient deuterostome origins of vertebrate brain signalling centres
Pani, A. M., Mullarkey, E. E., Aronowicz, J., Assimacopoulos, S., Grove, E. A., & Lowe, C. J. (2012) · Nature · doi:10.1038/nature10838 · Cited by 252
Behavior-related gene regulatory networks: A new level of organization in the brain
Sinha, S., Jones, B. M., Traniello, I. M., Bukhari, S. A., Halfon, M. S., Hofmann, H. A., Huang, S., Katz, P. S., Keagy, J., Lynch, V. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921625117 · Cited by 85
Evolution of the bilaterian mouth and anus
Nielsen, C., Brunet, T., & Arendt, D. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0641-0 · Cited by 70
Metadata
- Authors
- Imai, K. S., Stolfi, A., Levine, M., & Satou, Y.
- Affiliations
- Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku,Kyoto, 606-8502, Japan.
- Department of Molecular and Cellular Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720, USA.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2009-01-15
- Volume
- 136
- Issue
- 2
- Pages
- 285-293
- ISSN
- 1477-9129
- 0950-1991
- Cited by
- 159
- References
- 42
- Language
- en
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