Cited by 80Gene Regulatory Network AnalysisNeurobiology and Insect Physiology ResearchNeural dynamics and brain function

Behavior-related gene regulatory networks: A new level of organization in the brain

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Sinha, Saurabh, Jones, Beryl M., Traniello, Ian M., Bukhari, Syed A., Halfon, Marc S., Hofmann, Hans A., Huang, Sui, Katz, Paul S. +7 more·2020·Proceedings of the National Academy of Sciences

Abstract

Neuronal networks are the standard heuristic model today for describing brain activity associated with animal behavior. Recent studies have revealed an extensive role for a completely distinct layer of networked activities in the brain—the gene regulatory network (GRN)—that orchestrates expression levels of hundreds to thousands of genes in a behavior-related manner. We examine emerging insights into the relationships between these two types of networks and discuss their interplay in spatial as well as temporal dimensions, across multiple scales of organization. We discuss properties expected of behavior-related GRNs by drawing inspiration from the rich literature on GRNs related to animal development, comparing and contrasting these two broad classes of GRNs as they relate to their respective phenotypic manifestations. Developmental GRNs also represent a third layer of network biology, playing out over a third timescale, which is believed to play a crucial mediatory role between neuronal networks and behavioral GRNs. We end with a special emphasis on social behavior, discuss whether unique GRN organization and cis -regulatory architecture underlies this special class of behavior, and review literature that suggests an affirmative answer.

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Crossref · 10.1073/pnas.1921625117

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Authors
Sinha, S., Jones, B. M., Traniello, I. M., Bukhari, S. A., Halfon, M. S., Hofmann, H. A., Huang, S., Katz, P. S., Keagy, J., Lynch, V. J., Sokolowski, M. B., Stubbs, L. J., Tabe-Bordbar, S., Wolfner, M. F., & Robinson, G. E.
Affiliations
  • University of Illinois Urbana-Champaign (US)
  • University at Buffalo, State University of New York (US)
  • The University of Texas at Austin (US)
  • Institute for Systems Biology (US)
  • University of Massachusetts Amherst (US)
  • Canadian Institute for Advanced Research (CA)
  • Cornell University (US)
Corresponding author
  • Sinha, Saurabh
  • Robinson, Gene E.
Venue
Proceedings of the National Academy of Sciences
Published
2020-07-13
Volume
117
Issue
38
Pages
23270-23279
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W3041336646
Cited by
80
References
115
Citations by year
2026: 3 · 2025: 19 · 2024: 10 · 2023: 20 · 2022: 12 · 2021: 9 · 2020: 7
FWCI
3.38
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
gene regulatory networks, neuronal networks, developmental gene regulatory networks, social behavior, gene expression regulation, brain organization, animal behavior
MeSH terms
Animals, Behavior, Brain, Humans, Gene Expression Regulation, Developmental, Gene Regulatory Networks

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