The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2
Open accessAbstract
The mouse blastocyst and stem cells derived from its tissue lineages provide a unique genetic system for examining the establishment and loss of pluripotency. The transcription factor Cdx2 plays a central role by repressing pluripotency genes, such as Oct4, and promoting extraembryonic trophoblast fate at the blastocyst stage. However, genetic evidence has suggested that Cdx2 does not work alone in the trophoblast lineage. We have used bioinformatic and functional genomic strategies to identify the transcription factor Gata3 as a trophoblast factor. We show Gata3 to be capable of inducing trophoblast fate in embryonic stem cells and driving trophoblast differentiation in trophoblast stem cells. In addition, Cdx2 is not required for Gata3-induced expression of a subset of trophoblast genes in embryonic stem cells. We show that Gata3 is coexpressed with Cdx2 in the blastocyst, but this does not depend on Cdx2. In the embryo, expression of Gata3, like that of Cdx2, depends on Tead4, and the expression of both factors becomes restricted to trophoblast by a mechanism that does not initially rely on Oct4. These observations suggest that Gata3 and Cdx2 can act in parallel pathways downstream of Tead4 to induce the expression of common and independent targets in the trophoblast lineage, whereas Oct4 is required for continued repression of trophoblast fate in the embryonic lineage.
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Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Cited by
Schiebinger, G., Shu, J., Tabaka, M., Cleary, B., Subramanian, V., Solomon, A., Gould, J., Liu, S., Lin, S., Berube, P., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.006 · Cited by 829
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
Schell, J. C., Wisidagama, D. R., Bensard, C., Zhao, H., Wei, P., Tanner, J., Flores, A., Mohlman, J., Sorensen, L. K., Earl, C. S., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3593 · Cited by 322
Lineage specification in the mouse preimplantation embryo
Chazaud, C., & Yamanaka, Y. (2016) · Development · doi:10.1242/dev.128314 · Cited by 317
Hemberger, M., Udayashankar, R., Tesar, P., Moore, H., & Burton, G. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq128 · Cited by 181
TEAD family transcription factors in development and disease
Currey, L., Thor, S., & Piper, M. (2021) · Development · doi:10.1242/dev.196675 · Cited by 120
Schoenfelder, S., Mifsud, B., Senner, C. E., Todd, C. D., Chrysanthou, S., Darbo, E., Hemberger, M., & Branco, M. R. (2018) · Nature Communications · doi:10.1038/s41467-018-06666-4 · Cited by 54
Saotome, M., Poduval, D. B., Grimm, S. A., Nagornyuk, A., Gunarathna, S., Shimbo, T., Wade, P. A., & Takaku, M. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae025 · Cited by 15
Metadata
- Authors
- Ralston, A., Cox, B. J., Nishioka, N., Sasaki, H., Chea, E., Rugg-Gunn, P., Guo, G., Robson, P., Draper, J. S., & Rossant, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2010-02-01
- Volume
- 137
- Issue
- 3
- Pages
- 395-403
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1971582979
- Cited by
- 471
- References
- 1
- FWCI
- 12.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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