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Cited by 120Hippo pathway signaling and YAP/TAZDevelopmental Biology and Gene RegulationCongenital heart defects research

TEAD family transcription factors in development and disease

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Currey, Laura, Thor, Stefan, Piper, Michael·2021·Development
DOI 10.1242/dev.196675
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Abstract

The balance between stem cell potency and lineage specification entails the integration of both extrinsic and intrinsic cues, which ultimately influence gene expression through the activity of transcription factors. One example of this is provided by the Hippo signalling pathway, which plays a central role in regulating organ size during development. Hippo pathway activity is mediated by the transcriptional co-factors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which interact with TEA domain (TEAD) proteins to regulate gene expression. Although the roles of YAP and TAZ have been intensively studied, the roles played by TEAD proteins are less well understood. Recent studies have begun to address this, revealing that TEADs regulate the balance between progenitor self-renewal and differentiation throughout various stages of development. Furthermore, it is becoming apparent that TEAD proteins interact with other co-factors that influence stem cell biology. This Primer provides an overview of the role of TEAD proteins during development, focusing on their role in Hippo signalling as well as within other developmental, homeostatic and disease contexts.

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  • TEAD4 is a transcription factor involved in the Hippo signaling pathway.

    “TEAD4 is a transcription factor involved in the Hippo signaling pathway27, and future work is warranted to further examine its role in cardiac development.”

    From Transfer learning enables predictions in network biology (2023) · cites this paper as [27]

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Cited by

Sorted by citations

Authors
Currey, L., Thor, S., & Piper, M.
Affiliations
The University of Queensland (AU)
ORCID
Venue
Development
Publisher
The Company of Biologists
Published
2021-06-15
Volume
148
Issue
12
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.196675
OpenAlex
W3167338135
Cited by
120
References
7
Citations by year
2026: 24 · 2025: 33 · 2024: 33 · 2023: 18 · 2022: 9 · 2021: 3
FWCI
2.18
Type
journal article
Language
en
Open access
Locations
  • Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
Australian Research Council (DP180100017)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
TEAD transcription factors, Hippo signaling pathway, YAP, TAZ, stem cell potency, lineage specification, progenitor self-renewal, organ size control, transcriptional cofactors, developmental homeostasis, disease
MeSH terms
Animals, Cell Differentiation, Disease Susceptibility, DNA-Binding Proteins, Multigene Family, Homeostasis, Humans, Organ Specificity, Regeneration, Species Specificity, Stem Cells, Transcription Factors, Vertebrates, Biomarkers, Trans-Activators, Gene Expression Regulation, Developmental, Embryonic Development, Molecular Targeted Therapy

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