Drosophila neuroblasts: a model for stem cell biology

Homem, Catarina C. F., Knoblich, Juergen A.·2012·Development

DOI 10.1242/dev.080515

Cited by (476)

Items 301–400 of 476

Study of bantam miRNA expression in brain tumour resulted due to loss of polarity modules in Drosophila melanogaster
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Mnb/Dyrk1Aorchestrates a transcriptional network at the transition from self-renewing neurogenic progenitors to postmitotic neuronal precursors
Shaikh Mirja Nurunnabi, Francisco J. Tejedor · 2018 · Journal of Neurogenetics
Bantam regulates the axonal geometry of Drosophila larval brain by modulating actin regulator enabled
Animesh Banerjee, Jagat Kumar Roy · 2018 · Invertebrate Neuroscience
Ankle2, a Target of Zika Virus, Controls Asymmetric Cell Division of Neuroblasts and Uncovers a Novel Microcephaly Pathway
Nichole Link, Hyung-Lok Chung, Angad Jolly, Michael Withers, Burak Tepe, Benjamin Russell Arenkiel, P.S. Shah, Nevan J. Krogan, H. Aydın, Bilgen Bilge Geçkinli et al. · 2019 · SSRN Electronic Journal
CytoCensus: mapping cell identity and division in tissues and organs using machine learning
Martin Hailstone, Dominic Waithe, Tamsin J. Samuels, Lu Yang, Ita Costello, Yoav Arava, Elizabeth J. Robertson, Richard M. Parton, Ilan Davis · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
The RNA-binding protein, Imp specifies olfactory navigation circuitry and behavior in Drosophila
Aisha Hamid, Hannah C. Gattuso, Aysu Nora Caglar, M.V. Pillai, Theresa Steele, Alexa Gonzalez, Katherine I. Nagel, Mubarak Hussain Syed · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Atypical Protein Kinase C Promotes its own Asymmetric Localisation by Phosphorylating Cdc42 in the C. elegans zygote
John R. Packer, Alicia G. Gubieda, Aaron Brooks, Lars N. Deutz, Iolo J. Squires, Shona Ellison, Claudia Schneider, Sundar Ram Naganathan, Adam J. M. Wollman, Daniel J. Dickinson et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
A transcriptional clock of the human pluripotency transition
Louis Coussement, Matteo Ciarchi, Aljona Kolmogorova, Tim De Meyer, Steffen Rulands, Wolf Reik, Maria Rostovskaya · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
From the Making of a Neural Lineage to the Making of a Tumor: Lessons from the “Simple” Drosophila Brain
Julien Leclercq, Cédric Maurange · 2025 · Advances in experimental medicine and biology
Molecular Mechanisms of Drosophila Hematopoiesis
S. A. Sinenko · 2024 · Acta Naturae
Loss of function in Drosophila transcription factor Dif delays brain development in larvae resulting in aging adult brain
Ting Fang Tang, Jin Li, Bangwen Zhang, Liang Wen, Yuzhen Lu, Qihao Hu, Xiao‐Qiang Yu, Jie Zhang · 2024 · International Journal of Biological Macromolecules
Embryonic BPF exposure induces neurodevelopmental and neurobehavioral toxicity by affecting neural stem cell proliferation in Drosophila
Binquan Wang, Ziyi Yang, Ke Zhang, Lingling Wang, Yuanyuan Song, Qian Li, Mingkuan Sun · 2025 · Environmental Pollution
Asymmetry of centrosomes in Drosophila neural stem cells requires protein phosphatase 4
Roberto Carlos Segura, Emmanuel Gallaud, Adam von Barnau Sythoff, Kumar Aavula, Jennifer A. Taylor, Danielle Vahdat, Fabian Otte, Jan Pielage, Clemens Cabernard · 2025 · Molecular Biology of the Cell
Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination
Clara Sidor, Katja Röper · 2017 · The Journal of Cell Biology
Role of nuclear-cytoplasmic protein localization during Drosophila neuroblast development
Sophie E. Keegan, Sarah C. Hughes · 2020 · Genome
Progenitor‐derived ribosomal RNA supports protein synthesis in Drosophila neurons
Jade Fee, Mohamed Y. Aboukilila, Michael D. Cleary · 2021 · Natural Sciences
Non-lethal roles of the initiator caspase Dronc in Drosophila
Daniela Dominguez, Yun Fan · 2023 · Frontiers in Cell Death
Drosophila p53 tumor suppressor directly activates conserved asymmetric stem cell division regulators
Sandra Manzanero-Ortiz, Maribel Franco, Mahima Laxmeesha, Ana Carmena · 2024 · iScience
In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors
Karine Narbonne-Reveau, Andrea Erni, Norbert Eichner, S. H. Harsha Sankar, Surbhi Surbhi, Gunter Meister, Harold Cremer, Cédric Maurange, Christophe Béclin · 2025 · PLoS Genetics
Temporal correlation of elevated PRMT1 gene expression with mushroom body neurogenesis during bumblebee brain development
Cui Guan, Michaela Egertová, Clint J. Perry, Lars Chıttka, Alexandra Chittka · 2019 · Journal of Insect Physiology
Maintaining neural stem cell identity in the brain
Yanrui Jiang, Heinrich Reichert · 2014 · eLife
A Single-Cell Immunofluorescence Method for the Division Patterns Research of Mouse Bone Marrow-Derived Hematopoietic Stem Cells
Wanzhu Yang, Wenying Yu, Ting Chen, Xiaofang Wang, Fang Dong, Miner Xie, Yuemin Gong, Haoyue Liang, Weichao Fu · 2019 · Stem Cells and Development
Stem Cells and Asymmetric Cell Division
Rita Sousa‐Nunes, Frank Hirth · 2016 · Springer eBooks
Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila
Julia Hofstetter, Ayoola O. Ogunleye, André Kutschke, Lisa Marie Buchholz, Elmar Wolf, Thomas Raabe, Peter Gallant · 2023 · Life Science Alliance
Vertebrate Neurogenesis: Cell Polarity
Flavio R. Zolessi · 2016 · Encyclopedia of Life Sciences
JAK/STAT pathway promotes Drosophila neuroblast proliferation via the direct CycE regulation
Lijuan Du, Jian Wang · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Morphogenesis of a complex glial niche requires an interplay between cellular growth and fusion
M. Rujano, D. Briand, Bojana Ðelić, P. Spéder · 2021 · bioRxiv
Systematic analysis of YFP gene traps reveals common discordance between mRNA and protein across the nervous system
Josh Titlow, Maria Kiourlappou, Ana Palanca, Young Seok Lee, Dalia Gala, Darragh Ennis, Joyce J.S. Yu, Florence L. Young, David Miguel Susano Pinto, Sam Garforth et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
The neurodevelopmental transcriptome of the Drosophila melanogaster microcephaly gene abnormal spindle reveals a role for temporal transcription factors and the immune system in regulating brain size
M. Constanza Mannino, Mercedes Bartels Cassidy, Steven Florez, Zeid M. Rusan, Shalini Chakraborty, Todd Andrew Schoborg · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Developmental Genetic and Molecular Analysis ofDrosophilaCentral Complex Lineages
Gonzalo N Morales Chaya, Aisha Hamid, Adil Rashid Wani, Andrew Gutierrez, Mubarak Hussain Syed · 2024 · Cold Spring Harbor Protocols
The microcephaly protein WDR62 regulates cellular purine metabolism through the HSP70/HSP90 chaperone machinery
Matthew J. Morris, Yvonne Y.C. Yeap, Chi Chen, S. Sean Millard, Julia K. Pagan, Dominic C.H. Ng · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
An intercellular metabolic relay for brain sparing in Drosophila
Adrien Franchet, Yuhong Jin, Clare L. Newell, Victor Girard, Gérard Manière, Yaël Grosjean, Christopher Barrington, James I. MacRae, Ian S. Gilmore, Alex P. Gould · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
A space for time. Exploring temporal regulation of plant development across spatial scales
Yadhusankar Sasidharan, Vijayalakshmi Suryavanshi, Margot E. Smit · 2025 · The Plant Journal
Evaluating single-cell ATAC-seq atlasing technologies using sequence-to-function modeling
Hannah Dickmänken, Marta Wojno, Lukas Mahieu, Koen Theunis, Eren Can Ekşi, Valerie Christiaens, Niklas Kempynck, Florian V. De Rop, Natalie Roels, Katina I. Spanier et al. · 2026 · Nature Communications
aPKC and F-actin dynamics promote Hippo pathway polarity in asymmetrically dividing neuroblasts
Niranjan S. Joshi, Virginia Sullivan, Sherzod A. Tokamov, Richard G. Fehon · 2026 · Biology Open
Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in vivo
Rajini Chandrasegaram, Sara Gottardo, Abhilesh S Dhawanjewar, Antony M. Hynes-Allen, Bingxi Gao, Suvagata Roy Chowdhury, Luis Carlos Tábara, Michele Frison, Stavroula Petridi, Patrick Francis Chinnery et al. · 2026 · Developmental Cell
Importin-α2 mediates brain development, learning and memory consolidation inDrosophila
Christine N. Serway, Brian S. Dunkelberger, Denise Del Padre, Nicole W. C. Nolan, Stephanie J. Georges, Stephanie M. Freer, Andrew J. Andres, J. Steven de Belle · 2020 · Journal of Neurogenetics
Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma
Sylvie J. Lavictoire, Danny Jomaa, Alexander Gont, Karen E. Jardine, David P. Cook, Ian A.J. Lorimer · 2021 · Journal of Biological Chemistry
ASC proneural factors are necessary for chromatin remodeling during neuroectodermal to neuroblast fate transition to ensure the timely initiation of the neural stem cell program
Vasiliki Theodorou, Aikaterini Stefanaki, Minas Drakos, Dafne Triantafyllou, Christos Delidakis · 2022 · BMC Biology
Drosophila: a Tale of regeneration with MYC
Florenci Serras, Paola Bellosta · 2024 · Frontiers in Cell and Developmental Biology
Arsenic impairs Drosophila neural stem cell mitotic progression and sleep behavior in a tauopathy model
Temitope H. Adebambo, Fernanda Medina‐Flores, Shirley Zhang, Dorothy A. Lerit · 2025 · G3 Genes Genomes Genetics
The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development
Shalini Chakraborty, Steven Florez, Jack A. Govaerts, Abigail Hawke, Todd Andrew Schoborg · 2026 · Developmental Biology
Developmental and tissue specific changes of ubiquitin forms in Drosophila melanogaster
Ágota Nagy, Levente Kovács, Zoltán Lipinszki, Margit Pál, Péter Deák · 2018 · PLoS ONE
Stem Cells and Asymmetric Cell Division
Frank Hirth · 2010 · Springer eBooks
The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation
Xiao Xi, Lu Lu, Chun-Chun Zhuge, Xuebing Chen, Yuanfen Zhai, Jingjing Cheng, Haian Mao, Chang‐Ching Yang, Bertrand Chin‐Ming Tan, Yi‐Nan Lee et al. · 2017 · Scientific Reports
Drosophila Neural Stem Cells: A Primer for Understanding Mammalian Neural Development and Disease
Akanksha Verma, Malavika Elaveetil Santhosh, Richa Arya · 2019 · Springer eBooks
Sensitive-stage embryo irradiation affects embryonic neuroblasts and adult motor function
Ram Wagle, Young‐Han Song · 2022 · Molecular & Cellular Toxicology
Infection of the Developing Central Nervous System of Drosophila by Mammalian Eukaryotic and Prokaryotic Pathogens
Billel Benmimoun, Bente Winkler, Pauline Spéder · 2022 · BIO-PROTOCOL
A novel adipose loss-of-function mutant in Drosophila
Nicole A. Losurdo, Adriana Bibo, Jacob Bedke, Nichole Link · 2024 · Fly
Anglemetry of neural axis cell differentiation genes by structural pressurotopy of DNA loop strand segment tropy in reference to tissue macro-compliance
Hemant Sarin · 2019 · Translational Medicine Communications
Glial Hedgehog and lipid metabolism regulate neural stem cell proliferation in Drosophila
Qian Dong, Michael Zavortink, Francesca Froldi, Sofya Golenkina, Tammy Lam, Louise Y. Cheng · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Dense reconstruction of elongated cell lineages: overcoming suboptimum lineage encoding and sparse cell sampling
Ken Sugino, Rosa Linda Miyares, Isabel Espinosa-Medina, Hui-Min Chen, Christopher J. Potter, Tzumin Lee · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Developmental- and tissue-specific changes of ubiquitin forms in Drosophila melanogaster.
Ágota Nagy, Levente Kovács, Zoltán Lipinszki, Margit Pál, Péter Deák · 2018 · Preprints.org
A STIM dependent dopamine-insulin axis maintains the larval drive to feed and grow in Drosophila
Nandashree Kasturacharya, Jasmine Kaur Dhall, Gaiti Hasan · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in different organs in vivo
Rajini Chandrasegaram, Antony M. Hynes-Allen, Bingxi Gao, Abhilesh S Dhawanjewar, Michele Frison, Stavroula Petridi, Patrick Francis Chinnery, Hansong Ma, Jelle van den Ameele · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties
Buffy L. Eldridge-Thomas, Jerome G. Bohere, Chantal Roubinet, Alexandre Barthelemy, Tamsin J. Samuels, Felipe Karam Teixeira, Golnar Kolahgar · 2025 · PLoS Genetics
Latest News from the “Guardian”: p53 Directly Activates Asymmetric Stem Cell Division Regulators
Ana Carmena · 2025 · International Journal of Molecular Sciences
Mutational analysis of the Drosophila CMG helicase reveals relationships among chromosome integrity and the maintenance of spindle and centrosome structure
Lucia Graziadio, Livia Scatolini, Elisabetta Bucciarelli, Grazia Daniela Raffa, Silvia Bonaccorsi, Maurizio Gatti · 2025 · Genetics
The Hox Gene, abdominal-A , controls the size and timely mitotic entry of neural stem cells during CNS patterning in Drosophila
Papri Das, Smrithi Murthy, Eshan Abbas, Kristin White, Richa Arya · 2025 · Molecular Biology of the Cell
What the fruit fly can tell us about autosomal recessive primary microcephaly
Shalini Chakraborty, Steven Florez, Todd Andrew Schoborg · 2025 · Fly
Shaping the intestine: The role of cell morphology and spatial dynamics in development
Yuying Wang, Zhang Wen, Kaelyn Sumigray · 2025 · Current topics in developmental biology/Current Topics in Developmental Biology
Neurogenesis in the trunk and brain of the milkweed bug Oncopeltus fasciatus: insights beyond holometabolan models
Nitzan Alon, Ariel D. Chipman · 2025 · Frontiers in Zoology
Asymmetry and the cytoskeleton: Mechanisms of asymmetric neural stem cell division in Drosophila melanogaster
Clemens Cabernard · 2025 · Current topics in developmental biology/Current Topics in Developmental Biology
SWI/SNF ATPase Brahma and Notch signalling collaborate with CBP/p300 to regulate neural stem cell apoptosis in Drosophila larval central nervous system
Punam Bala, Viswadica Prakki, Rohit Joshi · 2026 · Developmental Biology
Mechanisms of asymmetric cell divisions in Drosophila melanogaster neuroblasts
Xuan‐Zhao Jiang, Carol Tang, Huanhuan Gao, Hongjuan Cui · 2014 · Invertebrate survival journal
Drosophila cytoplasmic dynein
Amanda L. Neisch, Adam W. Avery, Min-gang Li, Thomas S. Hays · 2017 · Elsevier eBooks
Mighty Fly: An Introduction to Drosophila
Vartika Sharma, Abhinava K. Mishra, Mousumi Mutsuddi, Ashim Mukherjee · 2019 · Springer eBooks
Methods for Creating Fly Models to Understand the Molecular Mechanisms Underlying Neurological Diseases
J. Nandan, Sonal Nagarkar-Jaiswal · 2019 · Springer eBooks
Role of glial niche in regulating neural stem cell proliferation in Drosophila central nervous system
Asif Bakshi, Rohit Joshi · 2020 · Journal of Neuroscience Research
A fly’s eye view of quiescent neural stem cells
Mahekta R. Gujar, Hongyan Wang · 2022 · Oxford Open Neuroscience
A novel proneural function of Asense is integrated with the sequential actions of Delta-Notch, L’sc and Su(H) to promote the neuroepithelial to neuroblast transition
Mercedes Martín, Shaikh Mirja Nurunnabi, Francisco José Gutiérrez-Aviñó, Francisco J. Tejedor · 2023 · PLoS Genetics
Imaging and Analysis of Drosophila Neural Stem Cell Asymmetric Division
Anne-Marie Berisha, Grégory Éot-Houllier, Régis Giet · 2024 · Methods in molecular biology
Multiple isoforms of the Activin-like receptor baboon differentially regulate proliferation and conversion behaviors of neuroblasts and neuroepithelial cells in the Drosophila larval brain
Gyunghee Lee, Aidan J. Peterson, Myung-Jun Kim, Michael B. O’Connor, Jae H. Park · 2024 · PLoS ONE
Neuronal Progenitors Suffer Genotoxic Stress in the Drosophila Clock Mutant per0
Nunzia Colonna Romano, Marcella Marchetti, Anna Marangoni, Laura Leo, Diletta Retrosi, Ezio Rosato, Laura Fanti · 2024 · Cells
Time-Lapse Imaging of Asymmetric Spindle Positioning During Endothelial Tip Cell Division in Angiogenesis In Vivo
Holly E. Lovegrove, Shane P. Herbert · 2024 · Methods in molecular biology
Unveiling the Tumor Suppressors: Insights from Drosophila
Xiaoyu Kuang, Xianjue Ma · 2025 · Advances in experimental medicine and biology
The role of chromosome/kinetochore-driven microtubule generation in Drosophila spindle assembly
Maurizio Gatti · 2025 · Chromosome Research
Tissue stem cells: the new actors in the aneuploidy field
Rita Brás, Cláudio E. Sunkel, Luís Pedro Resende · 2019 · Cell Cycle
Spindle Orientation-Independent Control of Cell Fate Determination by RGS3 and KIF20A
Runxiang Qiu, Kiyohito Murai, Qiang Lü · 2020 · Cerebral Cortex Communications
Neurogenesis in the Insect Central Nervous System and Its Peculiarities in the Brain Mushroom Bodies
А. А. Панов · 2022 · Entomological Review
Asymmetric Cell Division inDrosophilaNeuroblasts
Chwee Tat Koe, Hongyan Wang · 2016 · Encyclopedia of Life Sciences
Micro Computed Tomography as an Accessible Imaging Platform for Exploring Organism Development and Human Disease Modeling
Todd Andrew Schoborg, Samantha L. Smith, Lauren N. Smith, H Douglas Morris, Nasser M. Rusan · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
Regeneration in the adult Drosophila brain
Kassi L. Crocker, Khailee Marischuk, Stacey A. Rimkus, Hong Zhou, Jerry C. P. Yin, Grace Boekhoff‐Falk · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Kin17 drives dissociation of Mira from the centrosome in neuroblasts by regulating splicing of Flfl
Marisa Connell, Yonggong Xie, Rui Chen, Sijun Zhu · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Two distinct waves of transcriptome and translatome remodelling drive germline stem cell differentiation
Tamsin J. Samuels, Jinghua Gui, Daniel Gebert, Felipe Karam Teixeira · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Notch controls early temporal factor expression to control timing of Mushroom body neuroblast apoptosis
Kendall R. Branham, Chhavi Sood, Susan E. Doyle, Matthew C. Pahl, Sarah E Siegrist · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Differences in size and number of embryonic type-II neuroblast lineages are associated with divergent timing of central complex development between beetle and fly
Simon Rethemeier, Sonja Fritzsche, Dominik Mühlen, Gregor Bucher, Vera S. Hunnekuhl · 2024 · eLife
How serially homologous neuroblasts produce different temporal cohorts along the Drosophila larval body axis
Deeptha Vasudevan, Yiwen Wang, Hannah Carr, Elise Paniel, Sean Corcoran, Chris C Wreden, Elaine E. Kushkowski, Conor Lee-Smith, Ellie S. Heckscher · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Tumour-derived gliogenesis sustains dedifferentiation-dependent tumour growth in the Drosophila CNS
Edel Alvarez‐Ochoa, Qian Dong, Hannah Truong, Louise Y Cheng · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Differences in size and number of embryonic type-II neuroblast lineages correlate with divergent timing of central complex development between beetle and fly
Simon Rethemeier, Sonja Fritzsche, Dominik Mühlen, Gregor Bucher, Vera S. Hunnekuhl · 2025 · eLife
Human RAP2A homolog of the Drosophila asymmetric cell division regulator Rap2l targets the stemness of glioblastoma stem cells
Maribel Franco, Ricardo Gargini, Víctor Manuel Barberá, Daniel Becerra, Miguel Saceda, Ana Carmena · 2025 · eLife
Asymmetric centromere and gene locus positioning in Drosophila neural stem cells
Jennifer A. Taylor, Clemens Cabernard · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Differential usage of two, distinct DNA-binding domains regulates tissue-specific occupancy of the pioneer factor Zelda
Eliana F. Torres‐Zelada, Hideyuki Komori, Hsiao‐Yun Liu, Elizabeth D. Larson, Ally W. H. Yang, Zoe A Fitzpatrick, Timothy R. Hughes, Christine A. Rushlow, Cheng‐Yu Lee, Melissa M. Harrison · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Insights into brain development and disease from neurogenetic analyses in Drosophila melanogaster
Heinrich Reichert · 2014 · Journal of Biosciences
A Model for Cell Population Size Control Using Asymmetric Division
Mani Hamidi, Eldon G. Emberly · 2013 · PLoS ONE
A Genetic Screen for Genes Regulating the Generation of Drosophila Intermediate Neural Progenitor Cells
Thien. Luiu, Yong-Gang Xie, Xiaosu Li, Sijun Zhu · 2014 · SUNY Digital Repository Support (State University of New York System)
Membrane Traffic and Apicobasal Polarity in Drosophila Epithelial Cells
Barry J. Thompson · 2015 · Springer eBooks
Spatial Regulation of the Polarity Protein aPKC During Asymmetric Cell Division of Drosophila Neuroblasts
Mike Drummond · 2015 · Scholars' Bank (University of Oregon)
Identification of the molecular changes underlying head morphology variation in closely related Drosophila species
Montserrat Torres-Oliva · 2016
Regulation of the competence to respond to stem cell self-renewal factors by Earmuff
Bachelors Paper · 2014