Drosophila neuroblasts: a model for stem cell biology
Abstract
Drosophila neuroblasts, the stem cells of the developing fly brain, have emerged as a key model system for neural stem cell biology and have provided key insights into the mechanisms underlying asymmetric cell division and tumor formation. More recently, they have also been used to understand how neural progenitors can generate different neuronal subtypes over time, how their cell cycle entry and exit are coordinated with development, and how proliferation in the brain is spared from the growth restrictions that occur in other organs upon starvation. In this Primer, we describe the biology of Drosophila neuroblasts and highlight the most recent advances made using neuroblasts as a model system.
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Drosophila embryonic neuroblasts divide to produce a larger daughter that maintains stem cell identity and a smaller one destined for neuronal differentiation, via inheritance of neuronal determinants.
“Premier models for asymmetric cell division are Drosophila embryonic neuroblasts, neural stem/progenitor cells that divide to produce a larger daughter that maintains stem cell identity and a smaller one destined for neuronal differentiation, via inheritance of neuronal determinants (Homem and Knoblich, 2012).”
From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Homem and Knoblich, 2012
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- Authors
- Homem, C. C. F., & Knoblich, J. A.
- Affiliations
- Institute of Molecular Biotechnology (AT)
- Corresponding author
- Knoblich, Juergen A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2012-12-01
- Volume
- 139
- Issue
- 23
- Pages
- 4297-4310
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2100300374
- Cited by
- 476
- References
- 147
- Citations by year
- 2026: 27 · 2025: 42 · 2024: 42 · 2023: 31 · 2022: 31 · 2021: 39 · 2020: 48 · 2019: 42 · 2018: 40 · 2017: 34 · 2016: 29 · 2015: 22 · 2014: 35 · 2013: 13
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- Drosophila neuroblasts, neural stem cells, asymmetric cell division, tumor formation, neuronal subtype specification, cell cycle regulation, brain development, starvation, neural progenitor proliferation
- MeSH terms
- Animals, Brain, Cell Cycle, Cell Differentiation, Cell Division, Cell Transformation, Neoplastic, Drosophila, Neuroglia, Transcription Factors, Gene Expression Regulation, Developmental, Neurogenesis, Neural Stem Cells, Asymmetric Cell Division
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