Cited by 476Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsNeurobiology and Insect Physiology Research

Drosophila neuroblasts: a model for stem cell biology

Homem, Catarina C. F., Knoblich, Juergen A.·2012·Development

Abstract

Drosophila neuroblasts, the stem cells of the developing fly brain, have emerged as a key model system for neural stem cell biology and have provided key insights into the mechanisms underlying asymmetric cell division and tumor formation. More recently, they have also been used to understand how neural progenitors can generate different neuronal subtypes over time, how their cell cycle entry and exit are coordinated with development, and how proliferation in the brain is spared from the growth restrictions that occur in other organs upon starvation. In this Primer, we describe the biology of Drosophila neuroblasts and highlight the most recent advances made using neuroblasts as a model system.

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Crossref · 10.1242/dev.080515

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148 of 148 references verified0 citation errors · 0 not checkable

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  • Drosophila embryonic neuroblasts divide to produce a larger daughter that maintains stem cell identity and a smaller one destined for neuronal differentiation, via inheritance of neuronal determinants.

    “Premier models for asymmetric cell division are Drosophila embryonic neuroblasts, neural stem/progenitor cells that divide to produce a larger daughter that maintains stem cell identity and a smaller one destined for neuronal differentiation, via inheritance of neuronal determinants (Homem and Knoblich, 2012).”

    From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Homem and Knoblich, 2012

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Authors
Homem, C. C. F., & Knoblich, J. A.
Affiliations
Institute of Molecular Biotechnology (AT)
Corresponding author
Knoblich, Juergen A.
Venue
Development
Published
2012-12-01
Volume
139
Issue
23
Pages
4297-4310
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2100300374
Cited by
476
References
147
Citations by year
2026: 27 · 2025: 42 · 2024: 42 · 2023: 31 · 2022: 31 · 2021: 39 · 2020: 48 · 2019: 42 · 2018: 40 · 2017: 34 · 2016: 29 · 2015: 22 · 2014: 35 · 2013: 13
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Locations
  • Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
Drosophila neuroblasts, neural stem cells, asymmetric cell division, tumor formation, neuronal subtype specification, cell cycle regulation, brain development, starvation, neural progenitor proliferation
MeSH terms
Animals, Brain, Cell Cycle, Cell Differentiation, Cell Division, Cell Transformation, Neoplastic, Drosophila, Neuroglia, Transcription Factors, Gene Expression Regulation, Developmental, Neurogenesis, Neural Stem Cells, Asymmetric Cell Division

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