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Cited by 227Developmental Biology and Gene RegulationOcular Disorders and TreatmentsRetinal Development and Disorders

The cellular and molecular mechanisms of vertebrate lens development

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Cvekl, Aleš, Ashery-Padan, Ruth·2014·Development
DOI 10.1242/dev.107953PMC PMC4302924
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Abstract

The ocular lens is a model system for understanding important aspects of embryonic development, such as cell specification and the spatiotemporally controlled formation of a three-dimensional structure. The lens, which is characterized by transparency, refraction and elasticity, is composed of a bulk mass of fiber cells attached to a sheet of lens epithelium. Although lens induction has been studied for over 100 years, recent findings have revealed a myriad of extracellular signaling pathways and gene regulatory networks, integrated and executed by the transcription factor Pax6, that are required for lens formation in vertebrates. This Review summarizes recent progress in the field, emphasizing the interplay between the diverse regulatory mechanisms employed to form lens progenitor and precursor cells and highlighting novel opportunities to fill gaps in our understanding of lens tissue morphogenesis.

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  • RA signaling is responsible for the formation of the lens placode through the combination of the optic vessel (OV) and prospective lens ectoderm (PLE).

    “RA signaling is responsible for the formation of the lens placode through the combination of the optic vessel (OV) and prospective lens ectoderm (PLE).”

    From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [50]

    The section on lens placode formation says RA signaling contributes to lens induction and is active in the prospective lens ectoderm as the placode forms. It also says RA acts alongside BMP signaling and the Pax6, Six3 and Sox2 network; it does not describe RA as solely responsible or the optic vesicle and prospective lens ectoderm as combining to form the placode. No page number is provided in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Authors
Cvekl, A., & Ashery-Padan, R.
Affiliations
  • Albert Einstein College of Medicine (US)
  • Sackler School of Medicine and Sagol School of Neuroscience, Tel-Aviv University, 69978 Ramat Aviv, Tel Aviv, Israel
Corresponding author
Cvekl, Aleš
ORCID
Cvekl, Aleš
Venue
Development
Publisher
The Company of Biologists
Published
2014-12-01
Volume
141
Issue
23
Pages
4432-4447
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.107953
PMC
PMC4302924
OpenAlex
W2131142658
Cited by
227
References
6
Citations by year
2026: 13 · 2025: 16 · 2024: 25 · 2023: 21 · 2022: 22 · 2021: 19 · 2020: 22 · 2019: 21 · 2018: 17 · 2017: 18 · 2016: 19 · 2015: 14
FWCI
1.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Development (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
National Eye Institute (EY014237, R01EY014237, R01EY012200)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Ocular Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Keywords
lens development, lens induction, Pax6, lens epithelium, lens fiber cells, lens morphogenesis, gene regulatory networks, cell specification, eye development
MeSH terms
PAX6 Transcription Factor, Animals, Cell Cycle, Cell Differentiation, Eye Proteins, Humans, Lens, Crystalline, Models, Biological, Repressor Proteins, Species Specificity, Vertebrates, Signal Transduction, Homeodomain Proteins, Organogenesis, Paired Box Transcription Factors, Gene Regulatory Networks, Neural Plate

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