The DOI matches its Crossref record.
Calcium and cell cycle control
Abstract
The cell division cycle of the early sea urchin embryo is basic. Nonetheless, it has control points in common with the yeast and mammalian cell cycles, at START, mitosis ENTRY and mitosis EXIT. Progression through each control point in sea urchins is triggered by transient increases in intracellular free calcium. The Cai transients control cell cycle progression by translational and post-translational regulation of the cell cycle control proteins pp34 and cyclin. The START Cai transient leads to phosphorylation of pp34 and cyclin synthesis. The mitosis ENTRY Cai transient triggers cyclin phosphorylation. The motosis EXIT transient causes destruction of phosphorylated cyclin. We compare cell cycle regulation by calcium in sea urchin embryos to cell cycle regulation in other eggs and oocytes and in mammalian cells.
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Citations
Cited by
Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Generation, Control, and Processing of Cellular Calcium Signals
Carafoli, E., Santella, L., Branca, D., & Brini, M. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074183 · Cited by 531
Swann, K. (1990) · Development · doi:10.1242/dev.110.4.1295 · Cited by 447
Lighting the fuse at fertilization
Whitaker, M., & Swann, K. (1993) · Development · doi:10.1242/dev.117.1.1 · Cited by 323
Self-citationPotassium channels and regulation of proliferation of human melanoma cells.
Nilius, B., & Wohlrab, W. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp018938 · Cited by 203
Metadata
- Authors
- Whitaker, M., & Patel, R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1990-04-01
- Volume
- 108
- Issue
- 4
- Pages
- 525-542
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1807534989
- Cited by
- 433
- References
- 0
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- closed
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