The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis*
Abstract
The possible in vivo role of TGF-beta 1 in regulating various proteins of the extracellular matrix, including fibronectin, collagen I and III, and glycosaminoglycans, was examined by immunohistochemical methods during critical stages of lung morphogenesis in the 11-to 18-day-old mouse embryo. Sections of Bouin-fixed, paraf-fin-embedded whole embryos were exposed to polyclonal antibodies specific to synthetic peptides present in the precursor part of TGF-beta 1 (pro-TGF-beta 1), in the processed TGF-beta 1 (antibody CC), collagen J and HI, fibronectin, followed by the PAP or ABC technique to visualize the location of the antibody. GAG were stained with Alcian Blue 8GX. Our results indicate colocalization of TGF-beta 1 expression and that of matrix proteins in the developing lung when branching morphogenesis (cleft formation) and tissue stabilization occur. The presence of TGF-beta 1 at the epithelialmesenchymal interfaces of stalks and clefts at a time when matrix proteins can first be visualized in these areas, suggests a direct participation of the growth factor in the development of the basic architecture of the lung.
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Citations
Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Cell adhesion protein receptors as targets for transforming growth factor-$beta; action
IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485
Cited by
Miettinen, P. J., Ebner, R., Lopez, A. R., & Derynck, R. (1994) · The Journal of cell biology · doi:10.1083/jcb.127.6.2021 · Cited by 937
Transforming Growth Factor‐β: Major Role in Regulation of Extracellular Matrix
ROBERTS, A. B., HEINE, U. I., FLANDERS, K. C., & SPORN, M. B. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17931.x · Cited by 696
Self-citationMatrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted
Greenlee, K. J., Werb, Z., & Kheradmand, F. (2007) · Physiological Reviews · doi:10.1152/physrev.00022.2006 · Cited by 474
Taipale, J., Miyazono, K., Heldin, C., & Keski-Oja, J. (1994) · The Journal of cell biology · doi:10.1083/jcb.124.1.171 · Cited by 448
Piek, E., Moustakas, A., Kurisaki, A., Heldin, C.-H., & Dijke, P. T. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.24.4557 · Cited by 426
Metadata
- Authors
- Heine, U. I., Munoz, E. F., Flanders, K. C., Roberts, A. B., & Sporn, M. B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1990-05-01
- Volume
- 109
- Issue
- 1
- Pages
- 29-36
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2181382912
- Cited by
- 220
- References
- 2
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- closed
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