The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A homolog of Drosophila Notch expressed during mammalian development
Abstract
Drosophila Notch and the related Caenorhabditis elegans proteins lin-12 and glp-1 function as mediators of local cell-cell interactions required for cell-fate decisions during invertebrate development. To investigate the possibility that similar proteins play determinative roles during mammalian development, we isolated cDNA clones encoding rat Notch. The deduced amino acid sequence of this protein contains 36 epidermal growth factor (EGF)-like repeats, and is remarkably similar in both its extracellular and cytoplasmic domains to the sequence of Xenopus Xotch and Drosophila Notch. In the developing central nervous system, in situ hybridisation analyses revealed that Notch transcripts were dramatically restricted to the ventricular proliferative zones of embryonic neuroepithelia. Notch was also strongly expressed during development of non-neural tissues, such as hair follicles and tooth buds, whose correct differentiation requires epithelial-mesenchymal interactions. These data support the hypothesis that Notch plays an essential role in mammalian development and pattern formation that closely parallels its role in the development of invertebrates.
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Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127
Bettler, B., Boulter, J., Hermans-Borgmeyer, I., O'Shea-Greenfield, A., Deneris, E. S., Moll, C., Borgmeyer, U., Hollmann, M., & Heinemann, S. (1990) · Neuron · doi:10.1016/0896-6273(90)90213-y · Cited by 649
Cited by
Expression of a Delta homologue in prospective neurons in the chick
Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., & Ish-Horowicz, D. (1995) · Nature · doi:10.1038/375787a0 · Cited by 992
The transcription factor Sox10 is a key regulator of peripheral glial development
Britsch, S., Goerich, D. E., Riethmacher, D., Peirano, R. I., Rossner, M., Nave, K.-A., Birchmeier, C., & Wegner, M. (2001) · Genes & Development · doi:10.1101/gad.186601 · Cited by 914
Chenn, A., & McConnell, S. K. (1995) · Cell · doi:10.1016/0092-8674(95)90035-7 · Cited by 766
Notch1 is essential for postimplantation development in mice.
Swiatek, P. J., Lindsell, C. E., del Amo, F. F., Weinmaster, G., & Gridley, T. (1994) · Genes & Development · doi:10.1101/gad.8.6.707 · Cited by 734
Self-citationMorrison, S. J., Perez, S. E., Qiao, Z., Verdi, J. M., Hicks, C., Weinmaster, G., & Anderson, D. J. (2000) · Cell · doi:10.1016/s0092-8674(00)80860-0 · Cited by 721
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Metadata
- Authors
- Weinmaster, G., Roberts, V. J., & Lemke, G.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1991-01-09
- Volume
- 113
- Issue
- 1
- Pages
- 199-205
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1920902362
- Cited by
- 329
- References
- 2
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
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