The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo
Abstract
The differentiation in vitro of murine embryonic stem cells to embryoid bodies mimicks events that occur in vivo shortly before and after embryonic implantation. We have used this system, together with differential cDNA cloning, to identify genes the expression of which is regulated during early embryogenesis. Here we describe the isolation of several such cDNA clones, one of which corresponds to the gene H19. This gene is activated in extraembryonic cell types at the time of implantation, suggesting that it may play a role at this stage of development, and is subsequently expressed in all of the cells of the mid-gestation embryo with the striking exception of most of those of the developing central and peripheral nervous systems. After birth, expression of this gene ceases or is dramatically reduced in all tissues.
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Cites
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Cited by
Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Schöler, H., & Smith, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81769-9 · Cited by 3,392
Multipotent cell lineages in early mouse development depend on SOX2 function
Avilion, A. A., Nicolis, S. K., Pevny, L. H., Perez, L., Vivian, N., & Lovell-Badge, R. (2003) · Genes & Development · doi:10.1101/gad.224503 · Cited by 2,369
The functional role of long non-coding RNA in human carcinomas
Gibb, E. A., Brown, C. J., & Lam, W. L. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-38 · Cited by 1,619
Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype
Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al. (1995) · Science · doi:10.1126/science.7618084 · Cited by 1,179
Disruption of imprinting caused by deletion of the H19 gene region in mice
Leighton, P. A., Ingram, R. S., Eggenschwiler, J., Efstratiadis, A., & Tilghman, S. M. (1995) · Nature · doi:10.1038/375034a0 · Cited by 757
Metadata
- Authors
- Poirier, F., Chan, C.-T. J., Timmons, P. M., Robertson, E. J., Evans, M. J., & Rigby, P. W. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1991-12-01
- Volume
- 113
- Issue
- 4
- Pages
- 1105-1114
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1916533195
- Cited by
- 312
- References
- 1
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
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