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Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

Threadgill, David W., Dlugosz, Andrzej A., Hansen, Laura A., Tennenbaum, Tamar, Lichti, Ulrike, Yee, Della, LaMantia, Christian, Mourton, Tracy, Herrup, Karl, Harris, Raymond C., Barnard, John A., Yuspa, Stuart H., Coffey, Robert J., Magnuson, Terry·1995·Science
DOI 10.1126/science.7618084
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Abstract

Gene targeting was used to create a null allele at the epidermal growth factor receptor locus ( Egfr ). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.

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Research works printed but not linked: 23

  1. ADAMSON, E.D., EGF RECEPTOR ACTIVITIES IN MAMMALIAN DEVELOPMENT, MOLECULAR REPRODUCTION AND DEVELOPMENT 27: 16 (1990). · DOI
  2. AVNER, E.D., POLYPEPTIDE GROWTH-FACTORS IN METANEPHRIC GROWTH AND SEGMENTAL NEPHRON DIFFERENTIATION, PEDIATRIC NEPHROLOGY 4: 372 (1990). · DOI
  3. BARNARD, J.A., EPIDERMAL GROWTH FACTOR-RELATED PEPTIDES AND THEIR RELEVANCE TO GASTROINTESTINAL PATHOPHYSIOLOGY, GASTROENTEROLOGY 108: 564 (1995). · DOI
  4. BRICE, E.C., MODULATION OF MOUSE PREIMPLANTATION DEVELOPMENT BY EPIDERMAL GROWTH-FACTOR RECEPTOR ANTIBODIES, ANTISENSE RNA, AND DEOXYOLIGONUCLEOTIDES, DEVELOPMENTAL GENETICS 14: 174 (1993). · DOI
  5. CAREY, T.E., Journal of the National Cancer Institute. Monographs 13: 75 (1992).
  6. CHEN, J.D., EPIDERMAL GROWTH-FACTOR (EGF) PROMOTES HUMAN KERATINOCYTE LOCOMOTION ON COLLAGEN BY INCREASING THE ALPHA-2 INTEGRIN SUBUNIT, EXPERIMENTAL CELL RESEARCH 209: 216 (1993). · DOI
  7. DARDIK, A, COLOCALIZATION OF TRANSFORMING GROWTH FACTOR-ALPHA AND A FUNCTIONAL EPIDERMAL GROWTH-FACTOR RECEPTOR (EGFR) TO THE INNER CELL MASS AND PREFERENTIAL LOCALIZATION OF THE EGFR ON THE BASOLATERAL SURFACE OF THE TROPHECTODERM IN THE MOUSE BLASTOCYST, DEVELOPMENTAL BIOLOGY 154: 396 (1992). · DOI
  8. DONALDSON, R.W., EPIDERMAL GROWTH-FACTOR STIMULATES TYROSINE PHOSPHORYLATION IN THE NEONATAL MOUSE - ASSOCIATION OF A M(R) 55,000 SUBSTRATE WITH THE RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 8477 (1992).
  9. FOWLER, K.J., A MUTATION IN THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN WAVED-2 MICE HAS A PROFOUND EFFECT ON RECEPTOR BIOCHEMISTRY THAT RESULTS IN IMPAIRED LACTATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92: 1465 (1995).
  10. GLICK, A.B., LOSS OF EXPRESSION OF TRANSFORMING GROWTH-FACTOR-BETA IN SKIN AND SKIN TUMORS IS ASSOCIATED WITH HYPERPROLIFERATION AND A HIGH-RISK FOR MALIGNANT CONVERSION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 6076 (1993).
  11. LUETTEKE, N.C., TGF-ALPHA DEFICIENCY RESULTS IN HAIR FOLLICLE AND EYE ABNORMALITIES IN TARGETED AND WAVED-1 MICE, CELL 73: 263 (1993). · DOI
  12. LUETTEKE, N.C., THE MOUSE WAVED-2 PHENOTYPE RESULTS FROM A POINT MUTATION IN THE EGF RECEPTOR TYROSINE KINASE, GENES & DEVELOPMENT 8: 399 (1994). · DOI
  13. MANN, G.B., MICE WITH A NULL MUTATION OF THE TGF-ALPHA GENE HAVE ABNORMAL SKIN ARCHITECTURE, WAVY HAIR, AND CURLY WHISKERS AND OFTEN DEVELOP CORNEAL INFLAMMATION, CELL 73: 249 (1993). · DOI
  14. PARIA, B.C., PREIMPLANTATION EMBRYO DEVELOPMENT INVITRO - COOPERATIVE INTERACTIONS AMONG EMBRYOS AND ROLE OF GROWTH-FACTORS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 4756 (1990).
  15. PARIA, B.C., EXPRESSION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR GENE IS REGULATED IN MOUSE BLASTOCYSTS DURING DELAYED IMPLANTATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 55 (1993).
  16. POIRIER, F, THE MURINE H19-GENE IS ACTIVATED DURING EMBRYONIC STEM-CELL DIFFERENTIATION INVITRO AND AT THE TIME OF IMPLANTATION IN THE DEVELOPING EMBRYO, DEVELOPMENT 113: 1105 (1991). · DOI
  17. ROOP, D.R., REGULATED EXPRESSION OF DIFFERENTIATION-ASSOCIATED KERATINS IN CULTURED EPIDERMAL-CELLS DETECTED BY MONOSPECIFIC ANTIBODIES TO UNIQUE PEPTIDES OF MOUSE EPIDERMAL KERATINS, DIFFERENTIATION 35: 143 (1987). · DOI
  18. Sassoon, D., Guide to Techniques in Mouse Development: 384 (1993).
  19. TENHAVEOPBROEK, AAW, ULTRASTRUCTURAL FEATURES OF TYPE-II ALVEOLAR EPITHELIAL-CELLS IN EARLY EMBRYONIC MOUSE LUNG, ANATOMICAL RECORD 221: 846 (1988). · DOI
  20. TENNENBAUM, T, EXTRACELLULAR-MATRIX RECEPTORS AND MOUSE SKIN CARCINOGENESIS - ALTERED EXPRESSION LINKED TO APPEARANCE OF EARLY MARKERS OF TUMOR PROGRESSION, CANCER RESEARCH 52: 2966 (1992).
  21. WEINBERG, W.C., GROWTH-FACTORS SPECIFICALLY ALTER HAIR FOLLICLE CELL-PROLIFERATION AND COLLAGENOLYTIC ACTIVITY ALONE OR IN COMBINATION, DIFFERENTIATION 45: 168 (1990). · DOI
  22. WILEY, L.M., EPIDERMAL GROWTH-FACTOR RECEPTOR MESSENGER-RNA AND PROTEIN INCREASE AFTER THE 4-CELL PREIMPLANTATION STAGE IN MURINE DEVELOPMENT, DEVELOPMENTAL BIOLOGY 149: 247 (1992). · DOI
  23. WOOD, S.A., EFFECTS OF EPIDERMAL GROWTH-FACTOR ON PREIMPLANTATION MOUSE EMBRYOS, JOURNAL OF REPRODUCTION AND FERTILITY 85: 575 (1989). · DOI

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Metadata

Authors
Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., Barnard, J. A., Yuspa, S. H., Coffey, R. J., & Magnuson, T.
Affiliations
  • Department of Genetics, Case Western Reserve University, Cleveland, OH 44106-4955, USA.
  • Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Alzheimer Research Laboratory, Department of Neurology, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
  • Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.
  • Departments of Medicine and Cell Biology, Vanderbilt University, Nashville, TN 37232, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1995-07-14
Volume
269
Issue
5221
Pages
230-234
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.7618084
Cited by
1,179
References
0
Language
en

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