The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
TGF β 1 inhibits proliferation and has a chemotropic effect on mouse primordial germ cells in culture
Abstract
Primordial germ cells are the stem cells that provide the functional gametes of adult animals. In many animal groups they are set aside at the earliest stages of development, and migrate from their sites of first appearance to the sites where the gonad will form, the genital ridges. During this migration they proliferate. In the mouse embryo their numbers increase from less than one hundred to approximately four thousand during the period of their migration. In a previous paper we showed that both the proliferation and the direction of migration of mouse PGCs in culture were influenced by soluble factors released from their target tissue, the genital ridges. Studies on other stem cell populations have shown that complex combinations of growth factors control their proliferation, migration and differentiation. In this paper, we show that TGFβ1 inhibits proliferation of PGCs taken from 8.5 day old embryos and cultured on embryonic fibroblast feeder layers. We also show that the previously reported chemotropic effect of genital ridges in this culture system is mediated by TGFβ1, or a closely related molecule, released from the genital ridges.
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Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.
Postlethwaite, A. E., Keski-Oja, J., Moses, H. L., & Kang, A. H. (1987) · The Journal of experimental medicine · doi:10.1084/jem.165.1.251 · Cited by 777
Cell adhesion protein receptors as targets for transforming growth factor-$beta; action
IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485
Cited by
Regulatory Mechanisms in Stem Cell Biology
Morrison, S. J., Shah, N. M., & Anderson, D. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81867-x · Cited by 1,043
van den Hurk, R., & Zhao, J. (2005) · Theriogenology · doi:10.1016/j.theriogenology.2004.08.005 · Cited by 419
Time-Lapse Analysis of Living Mouse Germ Cell Migration
Molyneaux, K. A., Stallock, J., Schaible, K., & Wylie, C. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0436 · Cited by 337
Self-citationGnessi, L., Fabbri, A., & Spera, G. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.4.0310 · Cited by 306
An ovomucin-like protein on the surface of migrating primordial germ cells of the chick and rat
Halfter, W., Schurer, B., Hasselhorn, H. M., Christ, B., Gimpel, E., & Epperlein, H. H. (1996) · Development · doi:10.1242/dev.122.3.915 · Cited by 19
Metadata
- Authors
- Godin, I., & Wylie, C. C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1991-12-01
- Volume
- 113
- Issue
- 4
- Pages
- 1451-1457
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2187959282
- Cited by
- 160
- References
- 3
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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