The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo
Abstract
The localized developmental expression of murine platelet-derived growth factor A (PDGF-A) was compared to that of itsreceptor (Pdgfra). Our in situ hybridization study included germ layers of primitive streak embryos, early axial structures (dermatome, myotome, sclerotome, floor plate), the skin and some of its derivatives (hair and mammary gland), the developing fore-limb, the branchial arches and various sense organs (otic vesicle, olfactory epithelium and the eye). We report that PDGF-A and Pdgfra are expressed in separate, but adjacent cell layers in these structures and that in most, the ligand is expressed in the epithelium, whereas the receptor in the mesenchyme. This localization corresponds to classical experimental evidence for develop-mental interactions across cell layers. We suggest that the spatio-temporal regulation of PDGF-A and Pdgfra, and other related systems, represents one model for the spatial regulation of receptor-ligand interactions.
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Cites
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Lindahl, P., Karlsson, L., Hellström, M., Gebre-Medhin, S., Willetts, K., Heath, J. K., & Betsholtz, C. (1997) · Development · doi:10.1242/dev.124.20.3943 · Cited by 420
Origins of cardiac fibroblasts
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Metadata
- Authors
- Orr-Urtreger, A., & Lonai, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1992-08-01
- Volume
- 115
- Issue
- 4
- Pages
- 1045-1058
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2186753081
- Cited by
- 240
- References
- 1
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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