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Induction of floor plate differentiation by contact-dependent, homeogenetic signals
Abstract
The floor plate is located at the ventral midline of the neural tube and has been implicated in neural cell patterning and axon guidance. To address the cellular mechanisms involved in floor plate differentiation, we have used an assay that monitors the expression of floorplate-specific antigens in neural plate explants cultured in the presence of inducing tissues. Contact-mediated signals from both the notochord and the floor plate act directly on neural plate cells to induce floor plate differentiation. Floor plate induction is initiated medially by a signal from the notochord, but appears to be propagated to more lateral cells by homeogenetic signals that derive from medial floor plate cells. The response of neural plate cells to inductive signals declines with embryonic age, suggesting that the mediolateral extent of the floor plate is limited by a loss of competence of neural cells. The rostral boundary of the floor plate at the midbrain-forebrain junction appears to result from the lack of inducing activity in prechordal mesoderm and the inability of rostral neural plate cells to respond to inductive signals.
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Citations
Cited by
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154
Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. M., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90514-2 · Cited by 854
Self-citationLongitudinal organization of the anterior neural plate and neural tube
Shimamura, K., Hartigan, D. J., Martinez, S., Puelles, L., & Rubenstein, J. L. R. (1995) · Development · doi:10.1242/dev.121.12.3923 · Cited by 658
Identification of intrinsic determinants of midbrain dopamine neurons
Andersson, E., Tryggvason, U., Deng, Q., Friling, S., Alekseenko, Z., Robert, B., Perlmann, T., & Ericson, J. (2006) · Cell · doi:10.1016/j.cell.2005.10.037 · Cited by 587
Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessel, T. M., & Edlund, T. (1995) · Cell · doi:10.1016/0092-8674(95)90536-7 · Cited by 553
Self-citationDistribution of Sonic hedgehog peptides in the developing chick and mouse embryo
Martí, E., Takada, R., Bumcrot, D. A., Sasaki, H., & McMahon, A. P. (1995) · Development · doi:10.1242/dev.121.8.2537 · Cited by 336
Dorsalization of the neural tube by the non-neural ectoderm
Dickinson, M. E., Selleck, M. A. J., McMahon, A. P., & Bronner-Fraser, M. (1995) · Development · doi:10.1242/dev.121.7.2099 · Cited by 300
Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog
Bumcrot, D. A., Takada, R., & Mcmahon, A. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2294 · Cited by 300
Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
Altaba, A. R. I. (1998) · Development · doi:10.1242/dev.125.12.2203 · Cited by 199
The emergent design of the neural tube: prepattern, SHH morphogen and GLI code
Ruiz i Altaba, A., Nguyên, V., & Palma, V. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.08.005 · Cited by 118
Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
Sousa, V. H., & Fishell, G. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.04.008 · Cited by 106
Metadata
- Authors
- Placzek, M., Jessell, T. M., & Dodd, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-01-01
- Volume
- 117
- Issue
- 1
- Pages
- 205-218
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2097888799
- Cited by
- 273
- References
- 0
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
