Cited by 106Hedgehog Signaling Pathway StudiesDevelopmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain

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Sousa, Vitor H, Fishell, Gord·2010·Current Opinion in Genetics & Development

Abstract

Morphogens act during development to provide graded spatial information that controls patterning and cell lineage specification in the nervous system. The role of morphogen signaling in instructing the expression of downstream effector transcription factors has been well established. However, a key requirement for morphogen signaling is the existence of functional intracellular machinery able to mediate the appropriate response in target cells. Here we suggest that dynamic changes in the temporal responses to Shh in the developing ventral telencephalon occur through alterations in progenitor competence. We suggest these developmental changes in competence are mediated by a transcriptional mechanism that intrinsically integrates information from the distinct signaling pathways that act to pattern the telencephalic neuroepithelium.

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Crossref · 10.1016/j.gde.2010.04.008

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Authors
Sousa, V. H., & Fishell, G.
Affiliations
NYU Langone Health (US)
Corresponding author
Fishell, Gord
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2010-08
Volume
20
Issue
4
Pages
391-399
ISSN
0959-437X (ISSN-L)
OpenAlex
W2022089796
Cited by
106
References
73
Citations by year
2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 14 · 2013: 10 · 2012: 14
FWCI
1.01
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Genetics & Development (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH068469, R01MH071679, R37MH071679)
  • National Institute of Neurological Disorders and Stroke (R01NS032993, R01NS039007)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
Sonic hedgehog, morphogen signaling, temporal competence, ventral telencephalon, forebrain development, transcriptional regulation, signaling pathway integration, cell lineage specification
MeSH terms
Zinc Finger Protein GLI1, Thyroid Nuclear Factor 1, Animals, Cell Differentiation, Fibroblast Growth Factors, Nuclear Proteins, Telencephalon, Transcription Factors, Signal Transduction, Oncogene Proteins, Trans-Activators, Gene Expression Regulation, Developmental, Body Patterning, Mice, Hedgehog Proteins

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