The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth
Abstract
Duplication of the msh-like homeobox gene of Drosophila may be related to the evolution of the vertebrate head. The murine homologues of this gene, msx 1 and msx 2 are expressed in the developing craniofacial complex including the branchial arches, especially in regions of epithelial-mesenchymal organogenesis including the developing tooth. By performing in vitro recombination experiments using homochronic dental and non-dental epithelial and mesenchymal tissues from E10 to E18 mouse embryos, we have found that the maintenance of homeobox gene expression in the tooth is dependent upon tissue interactions. In homotypic recombinants, dental-type tissue interactions occur, leading to expression of both genes in a manner similar to that seen during in vivo development. msx 1 is expressed exclusively in mesenchyme, both in the dental papilla and follicle. msx 2 is expressed in the dental epithelium and only in the mesenchyme of the dental papilla. In heterotypic recombinants, the dental epithelium is able to induce msx 1 expression in non-dental mesenchyme, this potential being lost at the bell stage. In these recombinants msx 2 was induced by presumptive dental epithelium prior to the bud stage but not thereafter. The expression of msx 1 and msx 2 in dental mesenchyme requires the presence of epithelium until the early bell stage. However, whereas non-dental, oral epithelium is capable of maintaining expression of msx 1 in dental mesenchyme throughout tooth development, induction of msx 2 was temporally restricted suggesting regulation by a specific epithelial-mesenchymal interaction related to the inductive events of tooth formation. msx 1 and msx 2, as putative transcription factors, may play a role in regulating the expression of other genes during tooth formation. We conclude that expression of msx 1 in jaw mesenchyme requires a non-specific epithelial signal, whereas msx 2 expression in either epithelium or mesenchyme requires reciprocal interactions between specialized dental cell populations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian
Holland, P. W. H. (1991) · Gene · doi:10.1016/0378-1119(91)90182-b · Cited by 120
Cited by
van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 965
A human MSX1 homeodomain missense mutation causes selective tooth agenesis
Vastardis, H., Karimbux, N., Guthua, S. W., Seidman, J. G., & Seidman, C. E. (1996) · Nature Genetics · doi:10.1038/ng0896-417 · Cited by 721
Jabs, E. W., Müller, U., Li, X., Ma, L., Luo, W., Haworth, I. S., Klisak, I., Sparkes, R., Warman, M. L., Mulliken, J. B., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90379-5 · Cited by 677
Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells
Hollnagel, A., Oehlmann, V., Heymer, J., Rüther, U., & Nordheim, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19838 · Cited by 527
Kratochwil, K., Dull, M., Farinas, I., Galceran, J., & Grosschedl, R. (1996) · Genes & Development · doi:10.1101/gad.10.11.1382 · Cited by 425
Msx1 controls inductive signaling in mammalian tooth morphogenesis
Chen, Y., Bei, M., Woo, I., Satokata, I., & Maas, R. (1996) · Development · doi:10.1242/dev.122.10.3035 · Cited by 391
Wnt/β-catenin signaling directs multiple stages of tooth morphogenesis
Liu, F., Chu, E. Y., Watt, B., Zhang, Y., Gallant, N. M., Andl, T., Yang, S. H., Lu, M.-M., Piccolo, S., Schmidt-Ullrich, R., et al. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2007.10.016 · Cited by 381
Periodontal ligament cell populations: The central role of fibroblasts in creating a unique tissue
Lekic, P., & McCulloch, C. A. G. (1996) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199606)245:2<327::aid-ar15>3.0.co;2-r · Cited by 344
McGowan, K. M., & Coulombe, P. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.469 · Cited by 318
Vaahtokari, A., Åberg, T., & Thesleff, I. (1996) · Development · doi:10.1242/dev.122.1.121 · Cited by 286
Self-citationMsx homeobox gene family and craniofacial development
ALAPPAT, S., ZHANG, Z. Y., & CHEN, Y. P. (2003) · Cell Research · doi:10.1038/sj.cr.7290185 · Cited by 278
Kettunen, P., & Thesleff, I. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199803)211:3<256::aid-aja7>3.0.co;2-g · Cited by 275
Self-citationLaurikkala, J., Kassai, Y., Pakkasjärvi, L., Thesleff, I., & Itoh, N. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.08.011 · Cited by 270
Self-citationRoles for Msx and Dlx homeoproteins in vertebrate development
Bendall, A. J., & Abate-Shen, C. (2000) · Gene · doi:10.1016/s0378-1119(00)00081-0 · Cited by 260
Metadata
- Authors
- Jowett, A. K., Vainio, S., Ferguson, M. W. J., Sharpe, P. T., & Thesleff, I.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-02-01
- Volume
- 117
- Issue
- 2
- Pages
- 461-470
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1959992381
- Cited by
- 223
- References
- 1
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
