Msx homeobox gene family and craniofacial development
Abstract
Vertebrate Msx genes are unlinked, homeobox-containing genes that bear homology to the Drosophila muscle segment homeobox gene. These genes are expressed at multiple sites of tissue-tissue interactions during vertebrate embryonic development. Inductive interactions mediated by the Msx genes are essential for normal craniofacial, limb and ectodermal organ morphogenesis, and are also essential to survival in mice, as manifested by the phenotypic abnormalities shown in knockout mice and in humans. This review summarizes studies on the expression, regulation, and functional analysis of Msx genes that bear relevance to craniofacial development in humans and mice. Key words: Msx genes, craniofacial, tooth, cleft palate, suture, development, transcription factor, signaling molecule.
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MSX2 belongs to the Msx family and is involved in bone development.
“MSX2 belongs to the Msx family, Antennapedia (ANTP) class of human homeobox genes, and has been reported to be involved in bone development, including skull and tooth formation20,21.”
From Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis (2025) · cites this paper as [21]
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- Authors
- ALAPPAT, S., ZHANG, Z. Y., & CHEN, Y. P.
- Affiliations
- Tulane University (US)
- Fujian Normal University (CN)
- Corresponding author
- CHEN, Yi Ping
- Venue
- Cell Research
- Published
- 2003-12
- Volume
- 13
- Issue
- 6
- Pages
- 429-442
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W1991941177
- Cited by
- 278
- References
- 128
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 14 · 2022: 12 · 2021: 18 · 2020: 12 · 2019: 11 · 2018: 16 · 2017: 8 · 2016: 16 · 2015: 16 · 2014: 16 · 2013: 13 · 2012: 19
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9796321)
- Louisiana Board of Regents (2000-05)
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (R01 DE12329, R01DE014044, R01 DE14044, P60-DE 13076, R01DE012329, P60DE013076)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Cleft Lip and Palate Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
- Keywords
- craniofacial development, tooth development, cleft palate, cranial sutures, limb development, tissue-tissue interactions, transcription factors, signaling molecules, gene expression regulation, knockout mice
- MeSH terms
- Animals, Cleft Palate, DNA-Binding Proteins, Ectoderm, Embryonic Induction, Genes, Homeobox, Humans, Maxillofacial Development, Mesoderm, Models, Biological, Morphogenesis, Mutation, Odontogenesis, Skull, Transcription Factors, Mice, Knockout, Homeodomain Proteins, Gene Expression Regulation, Developmental, Mice, MSX1 Transcription Factor
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