Cited by 278Developmental Biology and Gene RegulationCleft Lip and Palate ResearchCraniofacial Disorders and Treatments

Msx homeobox gene family and craniofacial development

ALAPPAT, Sylvia, ZHANG, Zun Yi, CHEN, Yi Ping·2003·Cell Research

Abstract

Vertebrate Msx genes are unlinked, homeobox-containing genes that bear homology to the Drosophila muscle segment homeobox gene. These genes are expressed at multiple sites of tissue-tissue interactions during vertebrate embryonic development. Inductive interactions mediated by the Msx genes are essential for normal craniofacial, limb and ectodermal organ morphogenesis, and are also essential to survival in mice, as manifested by the phenotypic abnormalities shown in knockout mice and in humans. This review summarizes studies on the expression, regulation, and functional analysis of Msx genes that bear relevance to craniofacial development in humans and mice. Key words: Msx genes, craniofacial, tooth, cleft palate, suture, development, transcription factor, signaling molecule.

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Crossref · 10.1038/sj.cr.7290185

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Authors
ALAPPAT, S., ZHANG, Z. Y., & CHEN, Y. P.
Affiliations
  • Tulane University (US)
  • Fujian Normal University (CN)
Corresponding author
CHEN, Yi Ping
Venue
Cell Research
Published
2003-12
Volume
13
Issue
6
Pages
429-442
ISSN
  • 1001-0602 (ISSN-L)
  • 1748-7838
OpenAlex
W1991941177
Cited by
278
References
128
Citations by year
2026: 6 · 2025: 7 · 2024: 10 · 2023: 14 · 2022: 12 · 2021: 18 · 2020: 12 · 2019: 11 · 2018: 16 · 2017: 8 · 2016: 16 · 2015: 16 · 2014: 16 · 2013: 13 · 2012: 19
FWCI
0.73
Type
journal article
Language
en
Open access
closed
Locations
  • Cell Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (9796321)
  • Louisiana Board of Regents (2000-05)
  • National Institutes of Health
  • National Institute of Dental and Craniofacial Research (R01 DE12329, R01DE014044, R01 DE14044, P60-DE 13076, R01DE012329, P60DE013076)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Cleft Lip and Palate Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
Keywords
craniofacial development, tooth development, cleft palate, cranial sutures, limb development, tissue-tissue interactions, transcription factors, signaling molecules, gene expression regulation, knockout mice
MeSH terms
Animals, Cleft Palate, DNA-Binding Proteins, Ectoderm, Embryonic Induction, Genes, Homeobox, Humans, Maxillofacial Development, Mesoderm, Models, Biological, Morphogenesis, Mutation, Odontogenesis, Skull, Transcription Factors, Mice, Knockout, Homeodomain Proteins, Gene Expression Regulation, Developmental, Mice, MSX1 Transcription Factor

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