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Analysis of genetic mosaics in developing and adult Drosophila tissues
Abstract
We have constructed a series of strains to facilitate the generation and analysis of clones of genetically distinct cells in developing and adult tissues of Drosophila. Each of these strains carries an FRT element, the target for the yeast FLP recombinase, near the base of a major chromosome arm, as well as a gratuitous cellautonomous marker. Novel markers that carry epitope tags and that are localized to either the cell nucleus or cell membrane have been generated. As a demonstration of how these strains can be used to study a particular gene, we have analyzed the developmental role of the Drosophila EGF receptor homolog. Moreover, we have shown that these strains can be utilized to identify new mutations in mosaic animals in an efficient and unbiased way, thereby providing an unprecedented opportunity to perform systematic genetic screens for mutations affecting many biological processes.
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Cited by
Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., & Hafen, E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00068-9 · Cited by 1,255
Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4
Böhni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B. F., Beckingham, K., & Hafen, E. (1999) · Cell · doi:10.1016/s0092-8674(00)80799-0 · Cited by 835
Xu, T., Wang, W., Zhang, S., Stewart, R. A., & Yu, W. (1995) · Development · doi:10.1242/dev.121.4.1053 · Cited by 799
Self-citationBoutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801
O'Neill, E. M., Rebay, I., Tjian, R., & Rubin, G. M. (1994) · Cell · doi:10.1016/0092-8674(94)90580-0 · Cited by 675
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Metadata
- Authors
- Xu, T., & Rubin, G. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-04-01
- Volume
- 117
- Issue
- 4
- Pages
- 1223-1237
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2159935247
- Cited by
- 2,041
- References
- 0
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Open access
- closed
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