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RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila
Abstract
We report the identification of RK2, a glial-specific home-odomain protein. RK2 is localized to the nucleus of virtually all embryonic and imaginal glial cells, with the exception of midline glia. Embryos mutant for the gene encoding RK2 are embryonic lethal but normal for early gliogenesis (birth, initial divisions and migration of glia) and axonogenesis (neuronal pathfinding and fasciculation). However, later in development, there are significantly fewer longitudinal glia that are spatially disorganized; in addition, there is a slight disorganization of axon fascicles and a defective nerve cord condensation. This suggests that RK2 is not required for early glial determination, but rather for aspects of glial differentiation or function that are required for embryonic viability.
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Citations
Cited by
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MacDonald, J. M., Beach, M. G., Porpiglia, E., Sheehan, A. E., Watts, R. J., & Freeman, M. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.028 · Cited by 523
Epigenetic Regulation of Learning and Memory by Drosophila EHMT/G9a
Kramer, J. M., Kochinke, K., Oortveld, M. A. W., Marks, H., Kramer, D., de Jong, E. K., Asztalos, Z., Westwood, J. T., Stunnenberg, H. G., Sokolowski, M. B., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000569 · Cited by 204
Isshiki, T., Takeichi, M., & Nose, A. (1997) · Development · doi:10.1242/dev.124.16.3099 · Cited by 148
Metadata
- Authors
- Campbell, G., Göring, H., Lin, T., Spana, E., Andersson, S., Doe, C. Q., & Tomlinson, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-10-01
- Volume
- 120
- Issue
- 10
- Pages
- 2957-2966
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2186946794
- Cited by
- 261
- References
- 0
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Campbell, G., Göring, H., Lin, T., Spana, E., Andersson, S., Doe, C. Q., & Tomlinson, A. (1994). RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila. Development. https://doi.org/10.1242/dev.120.10.2957
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