The Drosophila Cell Corpse Engulfment Receptor Draper Mediates Glial Clearance of Severed Axons
Open accessAbstract
Neuron-glia communication is central to all nervous system responses to trauma, yet neural injury signaling pathways remain poorly understood. Here we explore cellular and molecular aspects of neural injury signaling in Drosophila. We show that transected Drosophila axons undergo injury-induced degeneration that is morphologically similar to Wallerian degeneration in mammals and can be suppressed by the neuroprotective mouse Wlds protein. Axonal injury elicits potent morphological and molecular responses from Drosophila glia: glia upregulate expression of the engulfment receptor Draper, undergo dramatic changes in morphology, and rapidly recruit cellular processes toward severed axons. In draper mutants, glia fail to respond morphologically to axon injury, and severed axons are not cleared from the CNS. Thus Draper appears to act as a glial receptor for severed axon-derived molecular cues that drive recruitment of glial processes to injured axons for engulfment.
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It has been proposed that WldS or NMNATs protect neurons at a step common to many degenerative processes.
“Together with the broad protective effects of NMNAT found in Drosophila (21,23,88), it has been proposed that Wld S or NMNATs protect neurons at a step common to many degenerative processes.”
From CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy (2012) · cites this paper as [88]
The Results report that dNmnat protects severed Drosophila axons from Wallerian degeneration, and the Discussion identifies Nmnat activity as part of WldS neuroprotection. The paper does not propose that WldS or NMNATs act at a step common to many different degenerative processes; its findings here concern injury-induced axon degeneration. Page numbers are unavailable in our copy. (LLM, conf=0.84)
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- Authors
- MacDonald, J. M., Beach, M. G., Porpiglia, E., Sheehan, A. E., Watts, R. J., & Freeman, M. R.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Stanford University (US)
- Corresponding author
- Freeman, Marc R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 50
- Issue
- 6
- Pages
- 869-881
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1993076702
- Cited by
- 523
- References
- 1
- Citations by year
- 2026: 15 · 2025: 30 · 2024: 24 · 2023: 27 · 2022: 29 · 2021: 26 · 2020: 37 · 2019: 23 · 2018: 23 · 2017: 27 · 2016: 18 · 2015: 18 · 2014: 29 · 2013: 26 · 2012: 42
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2639 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- drapers, engulfment receptor, axonal injury, Wallerian degeneration, axonal degeneration, neuron-glia communication
- MeSH terms
- Animals, Axons, Drosophila, Membrane Proteins, Nerve Tissue Proteins, Neuroglia, Wallerian Degeneration, Drosophila Proteins, Animals, Genetically Modified
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