The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway
Abstract
Genetic data from Drosophila have suggested a functional relationship between the novel cytoplasmic protein encoded by the deltex locus and the transmembrane receptor encoded by Notch. We have demonstrated a direct interaction between these proteins from expression studies conducted in cultured cells, in yeast, and in the imaginal wing disc. deltex binds specifically to the Notch ankyrin repeats, a region that is crucial for Notch signaling and that constitutes the most conserved domain among Notch family members. In addition, we present a new Notch allele, Nsu42c, that is associated with a missense mutation within the fifth ankyrin repeat. In addition to representing a new class of viable Notch allele, this mutation behaves similarly to mutations of deltex and further implicates the ankyrin repeats in Notch function.
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Citations
Cites
Drosophila abl and genetic redundancy in signal transduction
HOFFMANN, F. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90254-f · Cited by 62
Cited by
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Self-citationArtavanis-Tsakonas, S., Matsuno, K., & Fortini, M. E. (1995) · Science · doi:10.1126/science.7716513 · Cited by 1,303
Self-citationNotch signaling: simplicity in design, versatility in function
Andersson, E. R., Sandberg, R., & Lendahl, U. (2011) · Development · doi:10.1242/dev.063610 · Cited by 950
The ankyrin repeat as molecular architecture for protein recognition
Mosavi, L. K., Cammett, T. J., Desrosiers, D. C., & Peng, Z. (2004) · Protein Science · doi:10.1110/ps.03554604 · Cited by 907
O'Neill, E. M., Rebay, I., Tjian, R., & Rubin, G. M. (1994) · Cell · doi:10.1016/0092-8674(94)90580-0 · Cited by 675
Metadata
- Authors
- Diederich, R. J., Matsuno, K., Hing, H., & Artavanis-Tsakonas, S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-03-01
- Volume
- 120
- Issue
- 3
- Pages
- 473-481
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1897178313
- Cited by
- 207
- References
- 1
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Diederich, R. J., Matsuno, K., Hing, H., & Artavanis-Tsakonas, S. (1994). Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development. https://doi.org/10.1242/dev.120.3.473
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
