Notch signaling: simplicity in design, versatility in function

Smad-dependent and Smad-independent pathways in TGF-β family signalling

Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,370 · see citing works

Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

Weng, A. P., Ferrando, A. A., Lee, W., Morris, J. P., Silverman, L. B., Sanchez-Irizarry, C., Blacklow, S. C., Look, A. T., & Aster, J. C. (2004) · Science · doi:10.1126/science.1102160 · Cited by 2,706 · see citing works

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

Li, L., Krantz, I. D., Deng, Y., Genin, A., Banta, A. B., Collins, C. C., Qi, M., Trask, B. J., Kuo, W. L., Cochran, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-243 · Cited by 1,277 · see citing works

Notch signalling controls pancreatic cell differentiation

Apelqvist, Å., Li, H., Sommer, L., Beatus, P., Anderson, D. J., Honjo, T., de Angelis, M. H., Lendahl, U., & Edlund, H. (1999) · Nature · doi:10.1038/23716 · Cited by 1,158 · see citing works

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

Oda, T., ELKAHLOUN, A. G., Pike, B. L., Okajima, K., Krantz, I. D., Genin, A., Piccoli, D. A., Meltzer, P. S., Spinner, N. B., Collins, F. S., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-235 · Cited by 1,150 · see citing works

Hypoxia requires Notch signaling to maintain the undifferentiated cell state

Gustafsson, M. V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J. L., Poellinger, L., Lendahl, U., & Bondesson, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.010 · Cited by 1,109 · see citing works

A Novel Proteolytic Cleavage Involved in Notch Signaling

Brou, C., Logeat, F., Gupta-Rossi, N., Chable-Bessia, C., Bail, O. L., Doedens, J. R., Cumano, A., Roux, P., Black, R. A., & Israël, A. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80417-7 · Cited by 1,089 · see citing works

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformationPreprint

Timmerman, L., Grego‐Bessa, J., Raya, Á., Bertrán, E., Pérez-Pomares, J. M., Díez, J., Aranda, S., Palomo‐Ponce, S., McCormick, F., Izpisúa‐Belmonte, J. C., et al. (2003) · Genes & Development · doi:10.1101/gad.276304 · Cited by 986 · see citing works

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

Rangarajan, A., Talora, C., Okuyama, R., Nicolas, M., Mammucari, C., Oh, H., Aster, J. C., Krishna, S., METZGER, D., Chambon, P., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3427 · Cited by 867 · see citing works

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaPreprint

Weng, A. P., Millholland, J. M., Yashiro–Ohtani, Y., Arcangeli, M.-L., Lau, A. N., Wai, C., Bianco, C. D., Rodríguez, C. G., Sai, H., Tobias, J. W., et al. (2006) · Genes & Development · doi:10.1101/gad.1450406 · Cited by 863 · see citing works

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

Sahlgren, C., Gustafsson, M. V., Jin, S., Poellinger, L., & Lendahl, U. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802047105 · Cited by 823 · see citing works

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

Palomero, T., Lim, W. K., Odom, D. T., Sulis, M. L., Real, P. J., Margolin, A. A., Barnes, K., O’Neil, J., Neuberg, D. S., Weng, A. P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606108103 · Cited by 821 · see citing works

Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta

Itoh, M., Kim, C., Palardy, G. R., Oda, T., Jiang, Y., Maust, D. T., Yeo, S., Lorick, K. L., Wright, G. J., Ariza‐McNaughton, L., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00409-4 · Cited by 779 · see citing works

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

Rhyu, M. S., Jan, L. Y., & Jan, Y. N. (1994) · Cell · doi:10.1016/0092-8674(94)90112-0 · Cited by 770 · see citing works

Direct inhibition of the NOTCH transcription factor complex

Moellering, R. E., Cornejo, M., Davis, T. N., Bianco, C. D., Aster, J. C., Blacklow, S. C., Kung, A. L., Gilliland, D. G., Verdine, G. L., & Bradner, J. E. (2009) · Nature · doi:10.1038/nature08543 · Cited by 752 · see citing works

NOTCH2 Mutations Cause Alagille Syndrome, a Heterogeneous Disorder of the Notch Signaling Pathway

McDaniell, R. M., Warthen, D. M., Sanchez-Lara, P. A., Pai, A. A., Krantz, I. D., Piccoli, D. A., & Spinner, N. B. (2006) · The American Journal of Human Genetics · doi:10.1086/505332 · Cited by 747 · see citing works

Integration of TGF‐β/Smad and Jagged1/Notch signalling in epithelial‐to‐mesenchymal transition

Zavadil, J., C̆ermák, L., Soto-Nieves, N., & Böttinger, E. P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600069 · Cited by 747 · see citing works

The Notch1 receptor is cleaved constitutively by a furin-like convertase

Logeat, F., Chable-Bessia, C., Brou, C., Bail, O. L., Jarriault, S., Seidah, N. G., & Israël, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8108 · Cited by 737 · see citing works

Therapeutic antibody targeting of individual Notch receptors

Wu, Y., Cain-Hom, C., Choy, L., Hagenbeek, T. J., de Leon, G. P., Chen, Y., Finkle, D., Venook, R., Wu, X., Ridgway, J. B., et al. (2010) · Nature · doi:10.1038/nature08878 · Cited by 713 · see citing works

Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur

Alagille, D., Odièvre, M., Gautier, M., et al. (1975) · The Journal of Pediatrics · doi:10.1016/s0022-3476(75)80706-2 · Cited by 696 · see citing works

Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients

Joutel, A., Vahedi, K., Corpechot, C., Troesch, A., Chabriat, H., Vayssière, C., Cruaud, C., Maciazek, J., Weissenbach, J., Bousser, M.-G., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)08083-5 · Cited by 682 · see citing works

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

O’Neil, J., Grim, J. A., Strack, P. R., Rao, S. S., Tibbitts, D., Winter, C. G., Hardwick, J. S., Welcker, M., Meijerink, J. P. P., Pieters, R., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070876 · Cited by 662 · see citing works

Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): Review of 80 cases

Alagille, D., Estrada, A., Hadchouel, M., Gautler, M., Odièvre, M., & Dommergues, J. P. (1987) · The Journal of Pediatrics · doi:10.1016/s0022-3476(87)80153-1 · Cited by 650 · see citing works

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

Sprinzak, D., Lakhanpal, A., LeBon, L., Santat, L. A., Fontes, M. E., Anderson, G. A., García‐Ojalvo, J., & Elowitz, M. B. (2010) · Nature · doi:10.1038/nature08959 · Cited by 636 · see citing works

Mastermind Recruits CycC:CDK8 to Phosphorylate the Notch ICD and Coordinate Activation with Turnover

Fryer, C. J., White, B., & Jones, K. A. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.014 · Cited by 627 · see citing works

TORCs

Conkright, M. D., Canettieri, G., Screaton, R. A., Guzmán, E., Miraglia, L. J., Hogenesch, J. B., & Montminy, M. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.013 · Cited by 602 · see citing works

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

Sethi, N. S., Dai, X., Winter, C. G., & Kang, Y. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.022 · Cited by 573 · see citing works

Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling

Šestan, N., Artavanis‐Tsakonas, S., & RAKIC, P. T. (1999) · Science · doi:10.1126/science.286.5440.741 · Cited by 571 · see citing works

t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway

Tonon, G., Modi, S., Wu, L., Kubo, A., Coxon, A. B., Komiya, T., O’Neil, K. M., Stover, K., El‐Naggar, A. K., Griffin, J. D., et al. (2003) · Nature Genetics · doi:10.1038/ng1083 · Cited by 569 · see citing works

Notch Signaling in the Immune System

Radtke, F., Fasnacht, N., & MacDonald, H. R. (2010) · Immunity · doi:10.1016/j.immuni.2010.01.004 · Cited by 546 · see citing works

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutantsPreprint

Krebs, L. T., Shutter, J. R., Tanigaki, K., Honjo, T., Stark, K. L., & Gridley, T. (2004) · Genes & Development · doi:10.1101/gad.1239204 · Cited by 532 · see citing works

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

Uemura, T., Younger-Shepherd, S., Ackerman, L. D., Jan, L. Y., & Jan, Y. N. (1989) · Cell · doi:10.1016/0092-8674(89)90849-0 · Cited by 505 · see citing works

Regulation of Notch1 and Dll4 by Vascular Endothelial Growth Factor in Arterial Endothelial Cells: Implications for Modulating Arteriogenesis and Angiogenesis

Liu, Z., Shirakawa, T., Li, Y., Soma, A., Oka, M., Dotto, G. P., Fairman, R. M., Velazquez, O. C., & Herlyn, M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.14-25.2003 · Cited by 500 · see citing works

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

Parks, A. L., Klueg, K. M., Stout, J. R., & Muskavitch, M. A. T. (2000) · Development · doi:10.1242/dev.127.7.1373 · Cited by 494 · see citing works

Mechanisms of asymmetric cell division: flies and worms pave the way

Gönczy, P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2388 · Cited by 487 · see citing works

Notch signaling controls liver development by regulating biliary differentiation

Zong, Y., Panikkar, A., Xu, J., Antoniou, A., Raynaud, P., Lemaigre, F. P., & Stanger, B. Z. (2009) · Development · doi:10.1242/dev.029140 · Cited by 443 · see citing works

Defects in limb, craniofacial, and thymic development in Jagged2 mutant micePreprint

Jiang, R., Lan, Y., Chapman, H. D., Shawber, C. J., Norton, C. R., SERREZE, D. V., Weinmaster, G., & Gridley, T. (1998) · Genes & Development · doi:10.1101/gad.12.7.1046 · Cited by 422 · see citing works

Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled

Axelrod, J. D., Matsuno, K., Artavanis‐Tsakonas, S., & Perrimon, N. (1996) · Science · doi:10.1126/science.271.5257.1826 · Cited by 418 · see citing works

Induction of Cyclin D1 Transcription and CDK2 Activity by Notch ic : Implication for Cell Cycle Disruption in Transformation by Notch ic

Ronchini, C., & Capobianco, A. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5925-5934.2001 · Cited by 413 · see citing works

The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate

Micchelli, C. A., Rulifson, E. J., & Blair, S. S. (1997) · Development · doi:10.1242/dev.124.8.1485 · Cited by 413 · see citing works

The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog

Öberg, C., Li, J., Pauley, A. M., Wolf, E., Gurney, M. E., & Lendahl, U. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103992200 · Cited by 412 · see citing works

Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

Blokzijl, A., Dahlqvist, C., Reissmann, E., Falk, A., Moliner, A., Lendahl, U., & Ibáñez, C. F. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305112 · Cited by 396 · see citing works

Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate

Tanigaki, K., Nogaki, F., Takahashi, J. B., Tashiro, K., Kurooka, H., & Honjo, T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00179-9 · Cited by 394 · see citing works

Mutations in the human Delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis

Bulman, M. P., Kusumi, K., Frayling, T. M., McKeown, C., Garrett, C., Lander, E. S., Krumlauf, R. K., Hattersley, A. T., Ellard, S., & Turnpenny, P. D. (2000) · Nature Genetics · doi:10.1038/74307 · Cited by 393 · see citing works

Alterations of the Notch pathway in lung cancer

Westhoff, B., Colaluca, I. N., D’Ario, G., Donzelli, M., Tosoni, D., Volorio, S., Pelosi, G., Spaggiari, L., Mazzarol, G., Viale, G., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907781106 · Cited by 388 · see citing works

Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing

de Celis, J. F., & Bray, S. J. (1997) · Development · doi:10.1242/dev.124.17.3241 · Cited by 386 · see citing works

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

Guarani, V., Deflorian, G., Franco, C. A., Krüger, M., Phng, L., Bentley, K., Toussaint, L., Dequiedt, F., Mostoslavsky, R., Schmidt, M. H. H., et al. (2011) · Nature · doi:10.1038/nature09917 · Cited by 385 · see citing works

NUMB controls p53 tumour suppressor activity

Colaluca, I. N., Tosoni, D., Nuciforo, P., Senic-Matuglia, F., Galimberti, V., Viale, G., Pece, S., & Di Fiore, P. P. (2008) · Nature · doi:10.1038/nature06412 · Cited by 385 · see citing works

Notch1 and Notch2 Have Opposite Effects on Embryonal Brain Tumor Growth

Fan, X., Mikolaenko, I., Elhassan, I. O., Ni, X., Wang, Y., Ball, D. W., Brat, D. J., Perry, A., & Eberhart, C. G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1446 · Cited by 382 · see citing works

Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor

Gupta-Rossi, N., Bail, O. L., Gonen, H., Brou, C., Logeat, F., Six, E. M., Ciechanover, A. J., & Israël, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101343200 · Cited by 379 · see citing works

Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2

Hicks, C. D., Johnston, S. H., diSibio, G., Collazo, A., Vogt, T., & Weinmaster, G. (2000) · Nature Cell Biology · doi:10.1038/35019553 · Cited by 373 · see citing works

Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo

Dunwoodie, S. L., Henrique, D., Harrison, S. M., & Beddington, R. S. P. (1997) · Development · doi:10.1242/dev.124.16.3065 · Cited by 368 · see citing works

Canonical and Non-Canonical Notch Ligands

D’Souza, B., Meloty-Kapella, L., & Weinmaster, G. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92003-6 · Cited by 364 · see citing works

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron

Cheng, H., Kim, M., Valerius, M. T., et al. (2007) · Development · doi:10.1242/dev.02773 · Cited by 359 · see citing works

Notch3 signaling promotes the development of pulmonary arterial hypertension

Li, X., Zhang, X., Leathers, R. N., Makino, A., Huang, C., Parsa, P., Macías, J., Yuan, J. X. ‐., Jamieson, S. W., & Thistlethwaite, P. A. (2009) · Nature Medicine · doi:10.1038/nm.2021 · Cited by 358 · see citing works

The Notch Ligands, Jagged and Delta, Are Sequentially Processed by α-Secretase and Presenilin/γ-Secretase and Release Signaling Fragments

LaVoie, M. J., & Selkoe, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302659200 · Cited by 355 · see citing works

Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis

Phng, L., Potente, M., Leslie, J. D., Babbage, J. W., Nyqvist, D., Lobov, I. B., Ondr, J. K., Rao, S., Lang, R. A., Thurston, G., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.12.009 · Cited by 349 · see citing works

Up-regulation of Delta-like 4 Ligand in Human Tumor Vasculature and the Role of Basal Expression in Endothelial Cell Function

Patel, N. S., Li, J.-L., Generali, D., Poulsom, R., Cranston, D. W., & Harris, A. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1208 · Cited by 349 · see citing works

Cross-talk between Notch and the Estrogen Receptor in Breast Cancer Suggests Novel Therapeutic Approaches

Rizzo, P., Miao, H., D'Souza, G., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5744 · Cited by 343 · see citing works

fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development

Irvine, K. D., & Wieschaus, E. F. (1994) · Cell · doi:10.1016/0092-8674(94)90545-2 · Cited by 341 · see citing works

Regulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient

Bene, F. D., Wehman, A. M., Link, B. A., & Baier, H. (2008) · Cell · doi:10.1016/j.cell.2008.07.017 · Cited by 339 · see citing works

Phosphorylation by Glycogen Synthase Kinase-3β Down-regulates Notch Activity, a Link for Notch and Wnt Pathways

Espinosa, L., Inglés‐Esteve, J., Aguilera, C. N., & Bigas, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304001200 · Cited by 338 · see citing works

SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation

Wu, G., Lyapina, S., Das, I., Li, J., Gurney, M. E., Pauley, A. M., Chui, I., Deshaies, R. J., & Kitajewski, J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.21.7403-7415.2001 · Cited by 338 · see citing works

Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia

Vilimas, T., Mascarenhas, J., Palomero, T., Mandal, M., Buonamici, S., Meng, F., Thompson, B. J., Spaulding, C., Macaroun, S., Alegre, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1524 · Cited by 335 · see citing works

Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase

Qiu, L., Joazeiro, C. A. P., Fang, N., Wang, H., Elly, C., Altman, Y., Fang, D., Hunter, T. R., & Liu, Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007300200 · Cited by 332 · see citing works

Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats

Matsuno, K., Diederich, R. J., Go, M. J., et al. (1995) · Development · doi:10.1242/dev.121.8.2633 · Cited by 327 · see citing works

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

He, G., Luo, W., Li, P., Remmers, C. L., Netzer, W. J., Hendrick, J. P., Bettayeb, K., Flajolet, M., Gorelick, F. S., Wennogle, L. P., et al. (2010) · Nature · doi:10.1038/nature09325 · Cited by 326 · see citing works

The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling

Corada, M., Nyqvist, D., Orsenigo, F., Caprini, A., Giampietro, C., Taketo, M. M., Iruela‐Arispe, M. L., Adams, R. H., & Dejana, E. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.006 · Cited by 318 · see citing works

Asymmetric Rab11 Endosomes Regulate Delta Recycling and Specify Cell Fate in the Drosophila Nervous System

Emery, G., Hutterer, A., Berdnik, D., Mayer, B., Wirtz‐Peitz, F., González‐Gaitán, M., & Knoblich, J. A. (2005) · Cell · doi:10.1016/j.cell.2005.08.017 · Cited by 310 · see citing works

Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation

Liu, J., Sato, C., Cerletti, M., & Wagers, A. J. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92012-7 · Cited by 309 · see citing works

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

Çağavi, E., & Weinmaster, G. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00406-09 · Cited by 309 · see citing works

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

Acar, M., Jafar-Nejad, H., Takeuchi, H., Rajan, A., Ibrani, D., Rana, N. A., Pan, H., Haltiwanger, R. S., & Bellen, H. J. (2008) · Cell · doi:10.1016/j.cell.2007.12.016 · Cited by 306 · see citing works

Notch1 augments NF‐κB activity by facilitating its nuclear retention

Shin, H. M., Minter, L. M., Cho, O. H., Gottipati, S., Fauq, A. H., Golde, T. E., Sonenshein, G. E., & Osborne, B. A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600902 · Cited by 306 · see citing works

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

Simpson, M. A., Irving, M. D., Asilmaz, E., Gray, M. J., Dafou, D., Elmslie, F., Mansour, S., Holder, S. E., Brain, C. E., Burton, B. K., et al. (2011) · Nature Genetics · doi:10.1038/ng.779 · Cited by 305 · see citing works

TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity

Chen, F., Hasegawa, H., Schmitt‐Ulms, G., Kawarai, T., Böhm, C., Katayama, T., Gu, Y., Sanjo, N., Glista, M. J., Rogaeva, E. A., et al. (2006) · Nature · doi:10.1038/nature04667 · Cited by 301 · see citing works

Familial Tetralogy of Fallot caused by mutation in the jagged1 gene

Eldadah, Z. A. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.2.163 · Cited by 296 · see citing works

The Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear

Kiernan, A. E., Xu, J., & Gridley, T. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0020004 · Cited by 291 · see citing works

The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands

Ladi, E., Nichols, J. T., Ge, W., Miyamoto, A., Yao, C., Yang, L., Boulter, J., Sun, Y. E., Kintner, C. R., & Weinmaster, G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200503113 · Cited by 282 · see citing works

Chronic DLL4 blockade induces vascular neoplasms

Yan, M., Callahan, C. A., Beyer, J. C., Allamneni, K. P., Zhang, G., Ridgway, J. B., Niessen, K., & Plowman, G. D. (2010) · Nature · doi:10.1038/nature08751 · Cited by 280 · see citing works

Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development

Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N., Hatakeyama, S., Bessho, Y., Kageyama, R., Suda, T., & Nakayama, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312337200 · Cited by 276 · see citing works

Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis

Zhong, W., Jiang, M., Weinmaster, G., Jan, L. Y., & Jan, Y. N. (1997) · Development · doi:10.1242/dev.124.10.1887 · Cited by 275 · see citing works

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

van Tetering, G., van Diest, P. J., Verlaan-Klink, I., van der Wall, E., Kopan, R., & Vooijs, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.006775 · Cited by 274 · see citing works

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

Marcotullio, L. D., Ferretti, E., Greco, A., Smaele, E. D., Pò, A., Sico, M. A., Alimandi, M., Giannini, G., Maroder, M., Screpanti, I., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1510 · Cited by 274 · see citing works

Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition

Cohen, M., Γεωργίου, Μ., Stevenson, N. L., Miodownik, M. A., & Baum, B. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.006 · Cited by 272 · see citing works

Glycogen Synthase Kinase-3β Modulates Notch Signaling and Stability

Foltz, D. R., Santiago, M. C., Berechid, B. E., & Nye, J. S. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00888-6 · Cited by 271 · see citing works

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

Zheng, X., Linke, S., Dias, J. M., Zheng, X., Gradin, K., Wallis, T. P., Hamilton, B. R., Gustafsson, M. V., Ruas, J. L., Wilkins, S. E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711591105 · Cited by 271 · see citing works

Notch Signaling in the Vasculature

Gridley, T. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92009-7 · Cited by 270 · see citing works

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

Vaccari, T., Lu, H., Kanwar, R., Fortini, M., & Bilder, D. H. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708127 · Cited by 268 · see citing works

Identification of a Family of Mastermind-Like Transcriptional Coactivators for Mammalian Notch Receptors

Wu, L., Sun, T., Kobayashi, K., Gao, P., & Griffin, J. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7688-7700.2002 · Cited by 267 · see citing works

Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

Gazave, E., Lapébie, P., Richards, G. S., Brunet, F., Ereskovsky, A. V., Degnan, B. M., Borchiellini, C., Vervoort, M., & Renard, E. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-249 · Cited by 266 · see citing works

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

Cordle, J., Johnson, S., Tay, J. Z. Y., Roversi, P., Wilkin, M. B., de Madrid, B. H., Shimizu, H., Jensen, S. A., Whiteman, P., Jin, B., et al. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1457 · Cited by 264 · see citing works

Mechanism and Significance of cis-Inhibition in Notch Signalling

del Álamo, D., Rouault, H., & Schweisguth, F. (2011) · Current Biology · doi:10.1016/j.cub.2010.10.034 · Cited by 264 · see citing works

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch

Li, F., Lan, Y., Wang, Y., Wang, J., Yang, G., Meng, F., Han, H., Meng, A., Wang, Y., & Yang, X. Y. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.01.011 · Cited by 259 · see citing works

Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling

Okajima, T., Reddy, B. V. V. G., Matsuda, T., & Irvine, K. D. (2008) · BMC Biology · doi:10.1186/1741-7007-6-1 · Cited by 254 · see citing works

Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis

Estrach, S., Ambler, C. A., Celso, C. L., Hozumi, K., & Watt, F. M. (2006) · Development · doi:10.1242/dev.02644 · Cited by 254 · see citing works

Regulation of Notch signalling by non-visual β-arrestin

Mukherjee, A., Veraksa, A. N., Bauer, A., Rossé, C., Camonis, J., & Artavanis‐Tsakonas, S. (2005) · Nature Cell Biology · doi:10.1038/ncb1327 · Cited by 253 · see citing works

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development

Hald, J., Hjorth, J., German, M. S., Madsen, O. D., Serup, P., & Jensen, J. N. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00326-9 · Cited by 251 · see citing works

Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation

Dahlqvist, C., Blokzijl, A., Chapman, G., Falk, A., Dannaeus, K., Ibáñez, C. F., & Lendahl, U. (2003) · Development · doi:10.1242/dev.00834 · Cited by 251 · see citing works

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

Nichols, J. T., Miyamoto, A., Olsen, S. L., D’Souza, B., Yao, C., & Weinmaster, G. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200609014 · Cited by 249 · see citing works

SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function

Zhou, S. S., Fujimuro, M., Hsieh, J. J.-D., Chen, L., Miyamoto, A., Weinmaster, G., & Hayward, S. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2400-2410.2000 · Cited by 245 · see citing works

Mutation of the LUNATIC FRINGE Gene in Humans Causes Spondylocostal Dysostosis with a Severe Vertebral Phenotype

Sparrow, D. B., Chapman, G., Wouters, M. A., Whittock, N. V., Ellard, S., Fatkin, D., Turnpenny, P. D., Kusumi, K., Sillence, D., & Dunwoodie, S. L. (2005) · The American Journal of Human Genetics · doi:10.1086/498879 · Cited by 244 · see citing works

The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism

Zhang, N., Fu, Z., Linke, S., Chicher, J., Gorman, J. J., Visk, D., Haddad, G. G., Poellinger, L., Peet, D. J., Powell, F. L., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.001 · Cited by 244 · see citing works

Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells

Itoh, F., Itoh, S., Goumans, M., Valdimarsdóttir, G., Iso, T., Dotto, G. P., Hamamori, Y., Kedes, L., Kato, M., & ten Dijke, P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600065 · Cited by 237 · see citing works

Spectrum and Frequency of Jagged1 (JAG1) Mutations in Alagille Syndrome Patients and Their Families

Krantz, I. D., Colliton, R. P., Genin, A., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301875 · Cited by 235 · see citing works

Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate

Morimoto, M., Liu, Z., Cheng, H., Winters, N., Bader, D. M., & Kopan, R. (2010) · Journal of Cell Science · doi:10.1242/jcs.058669 · Cited by 235 · see citing works

Jagged1 mutations in Alagille syndrome

Spinner, N. B., Colliton, R. P., Crosnier, C., Krantz, I. D., Hadchouel, M., & Meunier-Rotival, M. (2000) · Human Mutation · doi:10.1002/1098-1004(2001)17:1 · Cited by 234 · see citing works

Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation

Mirsky, R., Woodhoo, A., Parkinson, D. B., Arthur‐Farraj, P., Bhaskaran, A., & Jessen, K. R. (2008) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2008.00168.x · Cited by 229 · see citing works

dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats

Baladrón, V., Ruiz-Hidalgo, M. J., Nueda, M. L., Díaz-Guerra, M. J. M., García-Ramírez, J. J., Bonvini, E., Gubina, E., & Laborda, J. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.10.001 · Cited by 226 · see citing works

Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye

Fanto, M., & Mlodzik, M. (1999) · Nature · doi:10.1038/17389 · Cited by 225 · see citing works

Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate

Diez, H., Fischer, A., Winkler, A., Hu, C., Hatzopoulos, A. K., Breier, G., & Gessler, M. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.09.009 · Cited by 224 · see citing works

Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor

Gupta-Rossi, N., Six, E. M., Bail, O. L., Logeat, F., Chastagner, P., Olry, A., Israël, A., & Brou, C. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310098 · Cited by 223 · see citing works

Social interactions among epithelial cells during tracheal branching morphogenesis

Ghabrial, A. S., & Krasnow, M. A. (2006) · Nature · doi:10.1038/nature04829 · Cited by 222 · see citing works

Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor

Coleman, M. L., McDonough, M. A., Hewitson, K. S., Coles, C., Mecinovicí, J., Edelmann, M., Cook, K. M., Cockman, M. E., Lancaster, D. E., Kessler, B. M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704102200 · Cited by 222 · see citing works

Numb Regulates Post-endocytic Trafficking and Degradation of Notch1

McGill, M. A., Dho, S. E., Weinmaster, G., & McGlade, C. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014845 · Cited by 221 · see citing works

Mutations in JAGGED1 gene are predominantly sporadic in Alagille syndrome

Crosnier, C., Driancourt, C., Raynaud, N., Dhorne‐Pollet, S., Pollet, N., Bernard, O., Hadchouel, M., & Meunier–Rotival, M. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70017-x · Cited by 219 · see citing works

Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

Xing, F., Okuda, H., Watabe, M., Kobayashi, A., Pai, S., Liu, W., Pandey, P., Fukuda, K., Hirota, S., Sugai, T., et al. (2011) · Oncogene · doi:10.1038/onc.2011.122 · Cited by 219 · see citing works

Target Selectivity of Vertebrate Notch Proteins

Ong, C., Cheng, H., Chang, L., Ohtsuka, T., Kageyama, R., Stormo, G. D., & Kopan, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506108200 · Cited by 218 · see citing works

Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

Joshi, I., Minter, L. M., Telfer, J. C., Demarest, R. M., Capobianco, A. J., Aster, J. C., Siciński, P., Fauq, A. H., Golde, T. E., & Osborne, B. A. (2008) · Blood · doi:10.1182/blood-2008-03-147967 · Cited by 215 · see citing works

Mechanistic Insights into Notch Receptor Signaling from Structural and Biochemical Studies

Kovall, R. A., & Blacklow, S. C. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92002-4 · Cited by 213 · see citing works

Liver‐specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice†‡

Geisler, F., Nagl, F., Mazur, P. K., Lee, M., Zimber‐Strobl, U., Strobl, L. J., Radtke, F., Schmid, R. M., & Siveke, J. T. (2008) · Hepatology · doi:10.1002/hep.22381 · Cited by 213 · see citing works

Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway

Diederich, R. J., Matsuno, K., Hing, H. K., & Artavanis‐Tsakonas, S. (1994) · Development · doi:10.1242/dev.120.3.473 · Cited by 207 · see citing works

Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS

Skeath, J. B., & Doe, C. Q. (1998) · Development · doi:10.1242/dev.125.10.1857 · Cited by 207 · see citing works

Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate

Warthen, D., Moore, E., Kamath, B., et al. (2006) · Human Mutation · doi:10.1002/humu.20310 · Cited by 206 · see citing works

Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancersPreprint

Krejci, A. B., & Bray, S. J. (2007) · Genes & Development · doi:10.1101/gad.424607 · Cited by 205 · see citing works

Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity

Hayward, P., Brennan, K. R., Sanders, P., Balayo, T., DasGupta, R., Perrimon, N., & Arias, A. M. (2005) · Development · doi:10.1242/dev.01724 · Cited by 204 · see citing works

Interaction Between Notch and Hif-α in Development and Survival of Drosophila Blood Cells

Mukherjee, T., Kim, W. S., Mandal, L., & Banerjee, U. K. (2011) · Science · doi:10.1126/science.1199643 · Cited by 199 · see citing works

Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

Coumailleau, F., Fürthauer, M., Knoblich, J. A., & González‐Gaitán, M. (2009) · Nature · doi:10.1038/nature07854 · Cited by 199 · see citing works

Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks

Alberi, L. A., Liu, S., Wang, Y. J., Badie, R., Smith‐Hicks, C. L., Wu, J., Pierfelice, T. J., Abazyan, B. N., Mattson, M. P., Kuhl, D., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.004 · Cited by 199 · see citing works

Sec15, a Component of the Exocyst, Promotes Notch Signaling during the Asymmetric Division of Drosophila Sensory Organ Precursors

Jafar‐Nejad, H., Andrews, H. K., Acar, M., Bayat, V., Wirtz‐Peitz, F., Mehta, S., Knoblich, J. A., & Bellen, H. J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.06.010 · Cited by 198 · see citing works

CHARACTER CHANGES CAUSED BY MUTATION OF AN ENTIRE REGION OF A CHROMOSOME IN DROSOPHILA

Mohr, O. L. (1919) · Genetics · doi:10.1093/genetics/4.3.275 · Cited by 197 · see citing works

Notch Signaling Regulates Platelet-Derived Growth Factor Receptor-β Expression in Vascular Smooth Muscle Cells

Jin, S., Hansson, E. M., Tikka, S., Lanner, F., Sahlgren, C., Farnebo, F. A., Baumann, M., Kalimo, H., & Lendahl, U. (2008) · Circulation Research · doi:10.1161/circresaha.107.167965 · Cited by 197 · see citing works

The Tumor Suppressor Gene hCDC4 Is Frequently Mutated in Human T-Cell Acute Lymphoblastic Leukemia with Functional Consequences for Notch Signaling

Malyukova, A., Dohda, T., von der Lehr, N., Akhoondi, S., Corcoran, M., Heyman, M. M., Spruck, C., Grandér, D., Lendahl, U., & Sangfelt, O. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4381 · Cited by 197 · see citing works

Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

Cayouette, M., & RAFF, M. C. (2002) · Nature Neuroscience · doi:10.1038/nn1202-1265 · Cited by 195 · see citing works

Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling

Hori, K., Fostier, M., Ito, M., Fuwa, T. J., Go, M. J., Okano, H., Baron, M., & Matsuno, K. (2004) · Development · doi:10.1242/dev.01448 · Cited by 194 · see citing works

Notch inhibition by the ligand Delta-Like 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis

Chapman, G., Sparrow, D. B., Kremmer, E., & Dunwoodie, S. L. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq529 · Cited by 192 · see citing works

Notch1 and TGFβ1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells

Samon, J. B., Champhekar, A. S., Minter, L. M., Telfer, J. C., Miele, L., Fauq, A. H., Das, P., Golde, T. E., & Osborne, B. A. (2008) · Blood · doi:10.1182/blood-2008-03-144980 · Cited by 191 · see citing works

Stabilized β-Catenin Functions through TCF/LEF Proteins and the Notch/RBP-Jκ Complex To Promote Proliferation and Suppress Differentiation of Neural Precursor Cells

Shimizu, T., Kagawa, T., Inoue, T., Nonaka, A., Takada, S., Aburatani, H., & Taga, T. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01962-07 · Cited by 188 · see citing works

Nrarp is a novel intracellular component of the Notch signaling pathwayPreprint

Lamar, E., Deblandre, G. A., Wettstein, D. A., Gawantka, V., Pollet, N., Niehrs, C., & Kintner, C. R. (2001) · Genes & Development · doi:10.1101/gad.908101 · Cited by 188 · see citing works

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

Tousseyn, T., Thathiah, A., Jorissen, E., Raemaekers, T., Konietzko, U., Reiß, K., Maes, E., Snellinx, A., Serneels, L., Nyabi, O., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805894200 · Cited by 188 · see citing works

Transcriptional control of stem cell maintenance in the Drosophila intestine

Bardin, A. J., Perdigoto, C. N., Southall, T. D., et al. (2010) · Development · doi:10.1242/dev.039404 · Cited by 186 · see citing works

Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila

de Joussineau, C., Soule, J. D., Martin, M., Anguille, C., Montcourrier, P., & Alexandre, D. (2003) · Nature · doi:10.1038/nature02157 · Cited by 184 · see citing works

Requirement of Notch activation during regeneration of the intestinal epithelia

Okamoto, R., Tsuchiya, K., Nemoto, Y., Akiyama, J., Nakamura, T., Kanai∥, T., & Watanabe, M. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90225.2008 · Cited by 182 · see citing works

The NOTCH4 locus is associated with susceptibility to schizophrenia

Wei, J., & Hemmings, G. P. (2000) · Nature Genetics · doi:10.1038/78044 · Cited by 180 · see citing works

Functions of Notch Signaling in the Immune System: Consensus and Controversies

Yuan, J. S., Kousis, P. C., Suliman, S., Visan, I., & Guidos, C. J. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132719 · Cited by 178 · see citing works

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

Aste-Amézaga, M., Zhang, N., Lineberger, J. E., Arnold, B. A., Toner, T. J., Gu, M., Huang, L., Vitelli, S., Vo, K. T., Haytko, P., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009094 · Cited by 176 · see citing works

Regulation of mammalian Notch signaling and embryonic development by the protein<i>O</i>-glucosyltransferase Rumi

Fernandez-Valdivia, R., Takeuchi, H., Samarghandi, A., Lopez, M., Leonardi, J., Haltiwanger, R. S., & Jafar-Nejad, H. (2011) · Development · doi:10.1242/dev.060020 · Cited by 175 · see citing works

Neuralized functions as an E3 ubiquitin ligase during Drosophila development

Yeh, E., Dermer, M., Commisso, C., et al. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00527-9 · Cited by 166 · see citing works

Pathogenic Mutations Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Differently Affect Jagged1 Binding and Notch3 Activity via the RBP/JK Signaling Pathway

Joutel, A., Monet, M., Domenga, V., Riant, F., & Tournier‐Lasserve, E. (2004) · The American Journal of Human Genetics · doi:10.1086/381506 · Cited by 164 · see citing works

Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo

Geffers, I., Serth, K., Chapman, G., Jaekel, R., Schuster-Gossler, K., Cordes, R., Sparrow, D. B., Kremmer, E., Dunwoodie, S. L., Klein, T., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702009 · Cited by 164 · see citing works

Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes

Davis, S. W., Castinetti, F., Carvalho, L. R. S., Ellsworth, B. S., Potok, M. A., Lyons, R. H., Brinkmeier, M. L., Raetzman, L. T., Carninci, P., Mortensen, A. H., et al. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.012 · Cited by 163 · see citing works

Numb Inhibits Membrane Localization of Sanpodo, a Four-Pass Transmembrane Protein, to Promote Asymmetric Divisions in Drosophila

O’Connor-Giles, K. M., & Skeath, J. B. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00226-0 · Cited by 161 · see citing works

Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic

Krejčı́, A., Bernard, F., Housden, B. E., Collins, S., & Bray, S. J. (2009) · Science Signaling · doi:10.1126/scisignal.2000140 · Cited by 161 · see citing works

Notch3 Mutations in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), a Mendelian Condition Causing Stroke and Vascular Dementia

Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48472.x · Cited by 160 · see citing works

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

Cohen, B. L., Shimizu, M., Izrailit, J., Ng, N. F. L., Bukhman, Y. V., Pan, J. G., Dering, J., & Reedijk, M. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0621-9 · Cited by 158 · see citing works

The Drosophila melanogaster Suppressor of deltex Gene, a Regulator of the Notch Receptor Signaling Pathway, Is an E3 Class Ubiquitin Ligase

Cornell, M. J., Evans, D. A. P., Mann, R. S., et al. (1999) · Genetics · doi:10.1093/genetics/152.2.567 · Cited by 158 · see citing works

Notch and Transforming Growth Factor-β (TGFβ) Signaling Pathways Cooperatively Regulate Vascular Smooth Muscle Cell Differentiation

Tang, Y., Urs, S., Boucher, J. M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.076414 · Cited by 157 · see citing works

Structural Rules and Complex Regulatory Circuitry Constrain Expression of a Notch- and EGFR-Regulated Eye Enhancer

Swanson, C. I., Evans, N. C., & Barolo, S. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.026 · Cited by 157 · see citing works

Drosophila HOPS and AP-3 Complex Genes Are Required for a Deltex-Regulated Activation of Notch in the Endosomal Trafficking Pathway

Wilkin, M. B., Tongngok, P., Gensch, N., Clémence, S., Motoki, M., Yamada, K., Hori, K., Taniguchi‐Kanai, M., Franklin, E., Matsuno, K., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.09.002 · Cited by 156 · see citing works

Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors

Enlund, F., Behboudi, A., Andrén, Y., et al. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.09.007 · Cited by 155 · see citing works

Roles for c-Myc in Self-renewal of Hematopoietic Stem Cells

Satoh, Y., Matsumura, I., Tanaka, H., Ezoe, S., Sugahara, H., Mizuki, M., Shibayama, H., Ishiko, E., Ishiko, J., Nakajima, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400407200 · Cited by 154 · see citing works

Notch Targets and Their Regulation

Bray, S. J., & Bernard, F. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92008-5 · Cited by 153 · see citing works

Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways

McElhinny, A., Li, J., & Wu, L. (2008) · Oncogene · doi:10.1038/onc.2008.228 · Cited by 152 · see citing works

Dynamic regulation of Notch signaling in neural progenitor cells

Kageyama, R., Ohtsuka, T., Shimojo, H., & Imayoshi, I. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.08.009 · Cited by 150 · see citing works

Interaction of Hypoxia-Inducible Factor-1α and Notch Signaling Regulates Medulloblastoma Precursor Proliferation and Fate

Pistollato, F., Rampazzo, E., Persano, L., Abbadi, S., Frasson, C., Denaro, L., D’Avella, D., Panchision, D. M., Puppa, A. D., Scienza, R., et al. (2010) · Stem Cells · doi:10.1002/stem.518 · Cited by 148 · see citing works

Amyloid Precursor Protein and Notch Intracellular Domains are Generated after Transport of their Precursors to the Cell Surface

Kaether, C., Schmitt, S., Willem, M., & Haass, C. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00396.x · Cited by 148 · see citing works

cis-Inhibition of Notch by Endogenous Delta Biases the Outcome of Lateral Inhibition

Miller, A. C., Lyons, E. L., & Herman, T. G. (2009) · Current Biology · doi:10.1016/j.cub.2009.06.042 · Cited by 148 · see citing works

MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans

Nadarajan, S., Govindan, J. A., McGovern, M., et al. (2009) · Development · doi:10.1242/dev.034603 · Cited by 147 · see citing works

Notch signaling maintains Leydig progenitor cells in the mouse testis

Tang, H., Brennan, J., Karl, J., Hamada, Y., Raetzman, L. T., & Capel, B. (2008) · Development · doi:10.1242/dev.024786 · Cited by 147 · see citing works

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

Wang, X.-D., Leow, C. C., Zha, J., Tang, Z., Modrusan, Z. D., Radtke, F., Aguet, M., de Sauvage, F. J., & Gao, W. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.009 · Cited by 145 · see citing works

Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notch ic -Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line

Jeffries, S., Robbins, D. J., & Capobianco, A. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3927-3941.2002 · Cited by 145 · see citing works

Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors

Yamamizu, K., Matsunaga, T., Uosaki, H., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200904114 · Cited by 145 · see citing works

Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless

Castro, B., Barolo, S., Bailey, A. M., et al. (2005) · Development · doi:10.1242/dev.01920 · Cited by 142 · see citing works

AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

Chastagner, P., Israël, A., & Brou, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002735 · Cited by 138 · see citing works

Novel mutations in DLL3, a somitogenesis gene encoding a ligand for the Notch signalling pathway, cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis

Turnpenny, P. D., Whittock, N. V., Duncan, J., Dunwoodie, S. L., Kusumi, K., & Ellard, S. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.5.333 · Cited by 137 · see citing works

Roles of Glycosylation in Notch Signaling

(2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92004-8 · Cited by 136 · see citing works

The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy

Buono, K. D., Robinson, G. W., Martin, C., Shi, S., Stanley, P., Tanigaki, K., Honjo, T., & Hennighausen, L. G. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.043 · Cited by 136 · see citing works

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation

Wendorff, A. A., Koch, U., Wunderlich, F. T., Wirth, S., Dubey, C., Brüning, J. C., MacDonald, H. R., & Radtke, F. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.014 · Cited by 136 · see citing works

Notch signaling is necessary for epithelial growth arrest by TGF-β

Niimi, H., Pardali, K., Vanlandewijck, M., Heldin, C., & Moustakas, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612129 · Cited by 135 · see citing works

NOTCH1 and NOTCH3 Coordinate Esophageal Squamous Differentiation Through a CSL-Dependent Transcriptional Network

Ohashi, S., Natsuizaka, M., Yashiro–Ohtani, Y., Kalman, R. A., Nakagawa, M., Wu, L., Klein–Szanto, A. J., Herlyn, M., Diehl, J. A., Katz, J. P., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.040 · Cited by 135 · see citing works

Identification of Glycosyltransferase 8 Family Members as Xylosyltransferases Acting on O-Glucosylated Notch Epidermal Growth Factor Repeats

Sethi, M. K., Buettner, F. F. R., Krylov, V. B., Takeuchi, H., Nifantiev, N. E., Haltiwanger, R. S., Gerardy‐Schahn, R., & Bakker, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c109.065409 · Cited by 134 · see citing works

Notch Signaling Regulates Bile Duct Morphogenesis in Mice

Lozier, J., McCright, B., & Gridley, T. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001851 · Cited by 134 · see citing works

Numb and α‐Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs

Hutterer, A., & Knoblich, J. A. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400500 · Cited by 129 · see citing works

The Drosophila Notch Inhibitor and Tumor Suppressor Gene lethal (2) giant discs Encodes a Conserved Regulator of Endosomal Trafficking

Jaekel, R., & Klein, T. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.09.019 · Cited by 127 · see citing works

Human Notch-1 Inhibits NF-κB Activity in the Nucleus Through a Direct Interaction Involving a Novel Domain

Wang, J., Shelly, L., Miele, L., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.289 · Cited by 126 · see citing works

Role of conserved intracellular motifs in Serrate signalling, cis‐inhibition and endocytosis

Glittenberg, M. T., Pitsouli, C., Garvey, C. F., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601337 · Cited by 125 · see citing works

Notch signaling regulates growth and differentiation in the mammalian lens

Rowan, S., Conley, K. W., Le, T. T., et al. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.06.002 · Cited by 125 · see citing works

Jagged1 (JAG1) mutations in patients with tetralogy of fallot or pulmonic stenosis

Bauer, R. C., Laney, A. O., Smith, R., Gerfen, J., Morrissette, J. J. D., Woyciechowski, S., Garbarini, J. L., Loomes, K. M., Krantz, I. D., Urbán, Z., et al. (2010) · Human Mutation · doi:10.1002/humu.21231 · Cited by 124 · see citing works

A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea

Zhang, N., Martin, G. V., Kelley, M. W., et al. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00522-4 · Cited by 123 · see citing works

Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1

Tagami, S., Okochi, M., Yanagida, K., Ikuta, A., Fukumori, A., Matsumoto, N., Ishizuka‐Katsura, Y., Nakayama, T., Itoh, N., Jiang, J., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00863-07 · Cited by 122 · see citing works

Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines

Dohda, T., Malyukova, A., Liu, L., Heyman, M. M., Grandér, D., Brodin, D., Sangfelt, O., & Lendahl, U. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.04.027 · Cited by 120 · see citing works

Notch Induces Myofibroblast Differentiation of Alveolar Epithelial Cells via Transforming Growth Factor- -Smad3 Pathway

Aoyagi, K., Maeno, T., Matsui, H., Ueno, M., Hara, K., Aoki, Y., Aoki, F., Shimizu, T., Doi, H., Kawai‐Kowase, K., et al. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0140oc · Cited by 118 · see citing works

Jag2‐Notch1 signaling regulates oral epithelial differentiation and palate development

Casey, L. M., Lan, Y., Cho, E., Maltby, K. M., Gridley, T., & Jiang, R. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20821 · Cited by 118 · see citing works

Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells

Yeung, T. M., Gandhi, S. C., & Bodmer, W. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014519107 · Cited by 117 · see citing works

The Dawn of Developmental Signaling in the MetazoaPreprint

Richards, G. S., & Degnan, B. M. (2009) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2009.74.028 · Cited by 117 · see citing works

Notch-Regulated Ankyrin-Repeat Protein Inhibits Notch1 Signaling: Multiple Notch1 Signaling Pathways Involved In T Cell Development

Yun, T. J., & Bevan, M. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.12.5834 · Cited by 116 · see citing works

Experimental selection of hypoxia-tolerant Drosophila melanogaster

Zhou, D., Udpa, N., Gersten, M. J., Visk, D., Bashir, A., Xue, J., Frazer, K. A., Posakony, J. W., Subramaniam, S., Bafna, V., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010643108 · Cited by 116 · see citing works

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

Arnett, K. L., Hass, M. R., McArthur, D. G., Ilagan, M. X. G., Aster, J. C., Kopan, R., & Blacklow, S. C. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1938 · Cited by 116 · see citing works

Molecular genetics of aortic valve disease

Garg, V. (2006) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000221578.18254.70 · Cited by 115 · see citing works

Prognostic Implications of NOTCH1 and FBXW7 Mutations in Adults With T-Cell Acute Lymphoblastic Leukemia Treated on the MRC UKALLXII/ECOG E2993 Protocol

Mansour, M. R., Sulis, M. L., Duke, V. M., Foroni, L., Jenkinson, S., Koo, K., Allen, C. G., Gale, R. E., Buck, G. A. N., Richards, S. M., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.0996 · Cited by 115 · see citing works

Differential Regulation of Transforming Growth Factor β Signaling Pathways by Notch in Human Endothelial Cells

Fu, Y., Chang, A. C. Y., Chang, L., Niessen, K. S., Eapen, S., Setiadi, A., & Karsan, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.011833 · Cited by 114 · see citing works

Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells

Bjornson, C. R. R., Cheung, T. H., Liu, L., Tripathi, P. V., Steeper, K. M., & Rando, T. A. (2012) · Stem Cells · doi:10.1002/stem.773 · Cited by 598 · see citing works

Spatial and Temporal Control of Senescence

Ito, Y., Hoare, M., & Narita, M. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.07.004 · Cited by 178 · see citing works

Notch1 functions as a negative regulator of lymphatic endothelial cell differentiation in the venous endothelium

Murtomaki, A., Uh, M. K., Choi, Y. K., Kitajewski, C., Borisenko, V., Kitajewski, J., & Shawber, C. J. (2013) · Development · doi:10.1242/dev.083865 · Cited by 110 · see citing works

The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis

Bansal, R., van Baarlen, J., Storm, G., & Prakash, J. (2015) · Scientific Reports · doi:10.1038/srep18272 · Cited by 107 · see citing works

Fine-tuning of the intracellular canonical Notch signaling pathway

Borggrefe, T., & Liefke, R. (2012) · Cell Cycle · doi:10.4161/cc.11.2.18995 · Cited by 102 · see citing works

The roles and regulation of TBX3 in development and disease

Khan, S. F., Damerell, V., Omar, R., Du Toit, M., Khan, M., Maranyane, H. M., Mlaza, M., Bleloch, J., Bellis, C., Sahm, B. D. B., et al. (2020) · Gene · doi:10.1016/j.gene.2019.144223 · Cited by 99 · see citing works

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Santio, N. M., Landor, S. K.-J., Vahtera, L., Ylä-Pelto, J., Paloniemi, E., Imanishi, S. Y., Corthals, G., Varjosalo, M., Manoharan, G. B., Uri, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9215 · Cited by 65 · see citing works

Notch signaling functions in lymphatic valve formation

Murtomaki, A., Uh, M. K., Kitajewski, C., Zhao, J., Nagasaki, T., Shawber, C. J., & Kitajewski, J. (2014) · Development · doi:10.1242/dev.101188 · Cited by 58 · see citing works

Genetic insights into non-syndromic Tetralogy of Fallot

Althali, N. J., & Hentges, K. E. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1012665 · Cited by 32 · see citing works

Notch signaling in embryology and cancer : molecular biology of notch signaling

Reichrath, J., & Reichrath, S. (2020) · Springer eBooks · Cited by 2 · see citing works

Genetic visualization of notch signaling in mammalian neurogenesis

Imayoshi, I., Shimojo, H., Sakamoto, M., Ohtsuka, T., & Kageyama, R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1151-x · Cited by 54 · see citing works

Modulation of Notch Signaling During Somitogenesis

Weinmaster, G., & Kintner, C. R. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.115434 · Cited by 59 · see citing works

Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling

Sethi, N. S., Yan, Y., Quek, D. Q. Y., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158634 · Cited by 72 · see citing works

TRAF6 is a novel regulator of Notch signaling in Drosophila melanogaster

Mishra, A. K., Sachan, N., Mutsuddi, M., et al. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.09.016 · Cited by 27 · see citing works