The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene
Abstract
The mouse T (Brachyury) gene is required for normal mesoderm development and the extension of the body axis. Recently, two mutant alleles of a zebrafish gene, no tail (ntl), have been isolated (Halpern, M. E., Ho., R. K., Walker, C. and Kimmel, C. B. (1993) Cell 75, 99-111). ntl mutant embryos resemble mouse T/T mutant embryos in that they lack a differentiated notochord and the caudal region of their bodies. We report here that this phenotype is caused by mutation of the zebrafish homologue of the T gene. While ntl embryos express mutant mRNA, they show no nuclear protein product. Later, expression of mRNA in mutants, but not in wild types, is greatly reduced along the dorsal midline where the notochord normally forms. This suggests that the protein is required for maintaining transcription of its own gene.
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Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Cited by
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
Self-citationMutations in the human Sonic Hedgehog gene cause holoprosencephaly
Roessler, E., Belloni, E., Gaudenz, K., Jay, P., Berta, P., Scherer, S. W., Tsui, L.-C., & Muenke, M. (1996) · Nature Genetics · doi:10.1038/ng1196-357 · Cited by 1,152
Thisse, C., Thisse, B., Schilling, T. F., & Postlethwait, J. H. (1993) · Development · doi:10.1242/dev.119.4.1203 · Cited by 877
Headwaters of the zebrafish — emergence of a new model vertebrate
Grunwald, D. J., & Eisen, J. S. (2002) · Nature Reviews Genetics · doi:10.1038/nrg892 · Cited by 733
Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
Bamshad, M., Lin, R. C., Law, D. J., Watkins, W. S., Krakowiak, P. A., Moore, M. E., Franceschini, P., Lala, R., Holmes, L. B., Gebuhr, T. C., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-311 · Cited by 540
Metadata
- Authors
- Schulte-Merker, S., Eeden, F. J. M. V., Halpern, M. E., Kimmel, C. B., & Nüsslein-Volhard, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-04-01
- Volume
- 120
- Issue
- 4
- Pages
- 1009-1015
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2104065792
- Cited by
- 623
- References
- 1
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- closed
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