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Cited by 770

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

Conlon, Frank L, Lyons, Karen M, Takaesu, Norma, Barth, Katrin S, Kispert, Andreas, Herrmann, Bernhard, Robertson, Elizabeth J·1994·Development
DOI 10.1242/dev.120.7.1919
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Abstract

The 413.d insertional mutation arrests mouse development shortly after gastrulation. nodal, a novel TGFb-related gene, is closely associated with the locus. The present study provides direct evidence that the proviral insertion causes a loss of function mutation. nodal RNA is initially detected at day 5.5 in the primitive ectoderm. Concomitant with gastrulation, expression becomes restricted to the proximal posterior regions of the embryonic ectoderm. nodal RNA is also expressed in the primitive endoderm overlying the primitive streak. A few hours later, expression is strictly confined to the periphery of the mature node. Interestingly 413.d mutant embryos show no morphological evidence for the formation of a primitive streak. Nonetheless, about 25% of mutant embryos do form randomly positioned patches of cells of a posterior mesodermal character. Data presented in this report demonstrate the involvement of a TGFb-related molecule in axis formation in mammals.

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Metadata

Authors
Conlon, F. L., Lyons, K. M., Takaesu, N., Barth, K. S., Kispert, A., Herrmann, B., & Robertson, E. J.
Venue
Development
Publisher
The Company of Biologists
Published
1994-07-01
Volume
120
Issue
7
Pages
1919-1928
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.120.7.1919
OpenAlex
W2147350988
Cited by
770
References
49
FWCI
7.23
Type
journal article
Language
en
Open access
closed

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