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nodal induces ectopic goosecoid and lim 1 expression and axis duplication in zebrafish
Abstract
One of the first intercellular signalling events in the vertebrate embryo leads to mesoderm formation and axis determination. In the mouse, a gene encoding a new member of the TGF-0 superfamily, nodal, is disrupted in a mutant deficient in mesoderm formation (Zhou et al., 1993, Nature 361, 543). nodal mRNA is found in prestreak mouse embryos, consistent with a role in the development of the dorsal axis. To examine the biological activities of nodal, we have studied the action of this factor in eliciting axis determination in the zebrafish, Danio rerio. Injection of nodal mRNA into zebrafish embryos caused the formation of ectopic axes that included notochord and somites. Axis duplication was preceded by the generation of an apparent ectopic shield (organizer equivalent) in nodal-injected embryos, as indicated by the appearance of a region overexpressing gsc and lim1; isolation and expression in the shield of the lim1 gene is reported here. These results suggest a role for a nodal-like factor in pattern formation in zebrafish.
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Cited by
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Topczewska, J. M., Postovit, L.-M., Margaryan, N. V., Sam, A., Hess, A. R., Wheaton, W. W., Nickoloff, B. J., Topczewski, J., & Hendrix, M. J. C. (2006) · Nature Medicine · doi:10.1038/nm1448 · Cited by 438
Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W. S., Robertson, E. J., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80331-7 · Cited by 374
Schier, A. F., Neuhauss, S. C. F., Helde, K. A., Talbot, W. S., & Driever, W. (1997) · Development · doi:10.1242/dev.124.2.327 · Cited by 359
Anatomy of zebrafish cerebellum and screen for mutations affecting its development
Bae, Y.-K., Kani, S., Shimizu, T., Tanabe, K., Nojima, H., Kimura, Y., Higashijima, S.-I., & Hibi, M. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.04.013 · Cited by 293
Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
Hart, A. H., Hartley, L., Sourris, K., Stadler, E. S., Li, R., Stanley, E. G., Tam, P. P. L., Elefanty, A. G., & Robb, L. (2002) · Development · doi:10.1242/dev.129.15.3597 · Cited by 229
Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a
Lange, L., Marks, M., Liu, J., Wittler, L., Bauer, H., Piehl, S., Bläß, G., Timmermann, B., & Herrmann, B. G. (2017) · Biology Open · doi:10.1242/bio.023200 · Cited by 19
Metadata
- Authors
- Toyama, R., O’Connell, M. L., Wright, C. V. E., Kuehn, M. R., & Dawid, I. B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-02-01
- Volume
- 121
- Issue
- 2
- Pages
- 383-391
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2137161806
- Cited by
- 161
- References
- 0
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
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