The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the somite
Abstract
The neural tube, floor plate and notochord are axial tissues in the vertebrate embryo which have been demonstrated to play a role in somite morphogenesis. Using in vitro co-culture of tissue explants, we have monitored inductive interactions of these axial tissues with the adjacent somitic mesoderm in chick embryos. We have found that signals from the neural tube and floor plate/notochord are necessary for expression of the myogenic bHLH regulators MyoD, Myf5 and myogenin in the somite. Eventually somitic expression of the myogenic bHLH genes is main-tained in the absence of the axial tissues. In organ culture, at early developmental stages (HH 11-), induction of myogenesis in the three most recently formed somites can be mediated by the neural tube together with the floor plate/notochord, while in more rostral somites (stages IV-IX) the neural tube without the floor plate/notochord is sufficient. By recombining somites and neural tubes from different axial levels of the embryo, we have found that a second signal is necessary to promote competence of the somite to respond to inducing signals from the neural tube. Thus, we propose that at least two signals from axial tissues work in combination to induce myogenic bHLH gene expression; one signal derives from the floor plate/notochord and the other signal derives from regions of the neural tube other than the floor plate.
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Citations
Cites
The MyoD family and myogenesis: Redundancy, networks, and thresholds
Weintraub, H. (1993) · Cell · doi:10.1016/0092-8674(93)90610-3 · Cited by 1,057
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Weinberg, E. S., Allende, M. L., Kelly, C. S., Abdelhamid, A., Murakami, T., Andermann, P., Doerre, O. G., Grunwald, D. J., & Riggleman, B. (1996) · Development · doi:10.1242/dev.122.1.271 · Cited by 648
Myogenic Regulatory Factors and the Specification of Muscle Progenitors in Vertebrate Embryos
Pownall, M. E., Gustafsson, M. K., & Emerson, C. P. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.012502.105758 · Cited by 577
Mutations affecting somite formation and patterning in the zebrafish, Danio rerio
van Eeden, F. J. M., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.-P., Jiang, Y.-J., Robert, D. A. K., et al. (1996) · Development · doi:10.1242/dev.123.1.153 · Cited by 521
Münsterberg, A. E., Kitajewski, J., Bumcrot, D. A., McMahon, A. P., & Lassar, A. B. (1995) · Genes & Development · doi:10.1101/gad.9.23.2911 · Cited by 511
Self-citationStructure and function of the notochord: an essential organ for chordate development
Stemple, D. L. (2005) · Development · doi:10.1242/dev.01812 · Cited by 443
Mutations affecting development of the midline and general body shape during zebrafish embryogenesis
Brand, M., Heisenberg, C.-P., Warga, R. M., Pelegri, F., Karlstrom, R. O., Beuchle, D., Picker, A., Jiang, Y.-J., Furutani-Seiki, M., Eeden, F. J. M. V., et al. (1996) · Development · doi:10.1242/dev.123.1.129 · Cited by 282
Determination versus differentiation and the MyoD family of transcription factors
Megeney, L. A., & Rudnicki, M. A. (1995) · Biochemistry and Cell Biology · doi:10.1139/o95-080 · Cited by 274
Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning
Hirsinger, E., Duprez, D., Jouve, C., Malapert, P., Cooke, J., & Pourquié, O. (1997) · Development · doi:10.1242/dev.124.22.4605 · Cited by 268
The extracellular matrix dimension of skeletal muscle development
Thorsteinsdóttir, S., Deries, M., Cachaço, A. S., & Bajanca, F. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.03.015 · Cited by 167
Halperin-Barlev, O., & Kalcheim, C. (2011) · Development · doi:10.1242/dev.065714 · Cited by 20
Metadata
- Authors
- Münsterberg, A. E., & Lassar, A. B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-03-01
- Volume
- 121
- Issue
- 3
- Pages
- 651-660
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2363598208
- Cited by
- 192
- References
- 1
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
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