The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Determination versus differentiation and the MyoD family of transcription factors
Abstract
The myogenic regulatory factors (MRFs) form a family of basic helix–loop–helix transcription factors consisting of Myf-5, MyoD, myogenin, and MRF4. The MRFs play key regulatory roles in the development of skeletal muscle during embryogenesis. Sequence homology, expression patterns, and genetargeting experiments have revealed a two-tiered subclassification within the MRF family. Myf-5 and MyoD are more homologous to one another than to the others, are expressed in myoblasts before differentiation, and are required for the determination or survival of muscle progenitor cells. By contrast, myogenin and MRF4 are more homologous to one another than to the others and are expressed upon differentiation, and myogenin is required in vivo as a differentiation factor while the role of MRF4 remains unclear. On this basis, MyoD and Myf-5 are classified as primary MRFs, as they are required for the determination of myoblasts, and myogenin and MRF4 are classified as secondary MRFs, as they likely function during terminal differentiation.Key words: MyoD, Myf-5, myogenin, MRF4, skeletal muscle.
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Citations
Cites
The MyoD family and myogenesis: Redundancy, networks, and thresholds
Weintraub, H. (1993) · Cell · doi:10.1016/0092-8674(93)90610-3 · Cited by 1,057
Cited by
MyoD is required for myogenic stem cell function in adult skeletal muscle
Megeney, L. A., Kablar, B., Garrett, K., Anderson, J. E., & Rudnicki, M. A. (1996) · Genes & Development · doi:10.1101/gad.10.10.1173 · Cited by 724
Self-citationMolecular mechanisms regulating myogenic determination and differentiation
Perry, R. (2000) · Frontiers in Bioscience · doi:10.2741/perry · Cited by 369
Hespel, P., Op't Eijnde, B., Leemputte, M. V., Ursø, B., Greenhaff, P. L., Labarque, V., Dymarkowski, S., Hecke, P. V., & Richter, E. A. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0625c.xd · Cited by 335
The importance of genetic redundancy in evolution
Láruson, Á. J., Yeaman, S., & Lotterhos, K. E. (2020) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2020.04.009 · Cited by 201
Wen, C., Jiang, X., Ding, L., Wang, T., & Zhou, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-02142-z · Cited by 50
Metadata
- Authors
- Megeney, L. A., & Rudnicki, M. A.
- Venue
- Biochemistry and Cell Biology
- Publisher
- Canadian Science Publishing
- Published
- 1995-09-01
- Volume
- 73
- Issue
- 9-10
- Pages
- 723-732
- ISSN
- 0829-8211 (ISSN-L)
- 1208-6002
- OpenAlex
- W2014716519
- Cited by
- 274
- References
- 1
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Megeney, L. A., & Rudnicki, M. A. (1995). Determination versus differentiation and the MyoD family of transcription factors. Biochemistry and Cell Biology. https://doi.org/10.1139/o95-080
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
