The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve
Abstract
Mice were generated with targeted disruptions in the hoxb-1 gene. Two separate mutations were created: the first disrupts only the homeodomain and the second inactivates the first exon as well as the homeodomain. The phenotypes associated with these two mutant alleles are indistinguishable in surviving adult mice. The predominant defect in these mutant mice is a failure to form the somatic motor component of the VIIth (facial) nerve, possibly through a failure to specify these neurons. The phenotype of hoxb-1 mutant homozygotes closely resembles features of the clinical profile associated with humans suffering from Bell’s Palsy or Moebius Syndrome. These animals should therefore provide a useful animal model for these human diseases.
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Cites
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Philippidou, P., & Dasen, J. S. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.020 · Cited by 423
Patterning the cranial neural crest: Hinbrain segmentation and hox gene plasticity
Trainor, P. A., & Krumlauf, R. (2000) · Nature Reviews Neuroscience · doi:10.1038/35039056 · Cited by 349
Homeobox Genes in Embryogenesis and Pathogenesis
Mark, M., Rijli, F. M., & Chambon, P. (1997) · Pediatric Research · doi:10.1203/00006450-199710000-00001 · Cited by 318
A developmental and genetic classification for midbrain-hindbrain malformations
Barkovich, A. J., Millen, K. J., & Dobyns, W. B. (2009) · Brain · doi:10.1093/brain/awp247 · Cited by 285
Initiation of Rhombomeric Hoxb4 Expression Requires Induction by Somites and a Retinoid Pathway
Gould, A., Itasaki, N., & Krumlauf, R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80513-9 · Cited by 273
Metadata
- Authors
- Goddard, Rossel, M., Manley, N. R., & Capecchi, M. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-10-01
- Volume
- 122
- Issue
- 10
- Pages
- 3217-3228
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1784887600
- Cited by
- 283
- References
- 57
- FWCI
- 18.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. https://app.cochat.ai/papers/10.1242/dev.122.10.3217
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- Goddard, Rossel, M., Manley, N. R., & Capecchi, M. R. (1996). Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development. https://doi.org/10.1242/dev.122.10.3217
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
