The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells
Abstract
The proteins necessary for signal transduction in cells responding to ligands of the TGF-β family are largely unknown. We have previously identified Mad (Mothers against dpp), a gene that interacts with the TGF-β family member encoded by decapentaplegic (dpp) in Drosophila. Assay of Mad’s role in the DPP-dependent events of embryonic midgut development demonstrates that Mad is required for any response of the visceral mesoderm or endoderm to DPP signals from the visceral mesoderm. Replacement of the normal DPP promoter with a heterologous (hsp70) promoter fails to restore DPP-dependent responses in Mad mutant midguts. Experiments utilizing Mad transgenes regulated by tissue-specific promoters show that MAD is required specifically in cells responding to DPP. Immunohistochemical studies localize MAD to the cytoplasm in all tissues examined. Experiments in Xenopus embryos demonstrate that Drosophila MAD can function in the signaling pathway of BMP-4, a vertebrate homolog of dpp. Based on these results, we propose that Mad is a highly conserved and essential element of the DPP signal transduction pathway.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., et al. (1996) · Science · doi:10.1126/science.271.5247.350 · Cited by 2,337
Cited by
Yang, X. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1280 · Cited by 889
Eppert, K., Scherer, S. W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L.-C., Bapat, B., Gallinger, S., Andrulis, I. L., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80128-2 · Cited by 845
BMP signalling in skeletal development, disease and repair
Salazar, V. S., Gamer, L. W., & Rosen, V. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.12 · Cited by 822
The molecular basis of lung morphogenesis
Warburton, D., Schwarz, M., Tefft, D., Flores-Delgado, G., Anderson, K. D., & Cardoso, W. V. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00325-1 · Cited by 729
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
Kim, J., Johnson, K., Chen, H. J., Carroll, S., & Laughon, A. (1997) · Nature · doi:10.1038/40906 · Cited by 527
Metadata
- Authors
- Newfeld, S. J., Chartoff, E. H., Graff, J. M., Melton, D. A., & Gelbart, W. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-07-01
- Volume
- 122
- Issue
- 7
- Pages
- 2099-2108
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2110632663
- Cited by
- 175
- References
- 1
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells. https://app.cochat.ai/papers/10.1242/dev.122.7.2099
- The paper
- Newfeld, S. J., Chartoff, E. H., Graff, J. M., Melton, D. A., & Gelbart, W. M. (1996). Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells. Development. https://doi.org/10.1242/dev.122.7.2099
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
