The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor
Abstract
Vertebrate limb formation has been known to be initiated by a factor(s) secreted from the lateral plate mesoderm. In this report, we provide evidence that a member of the fibroblast growth factor (FGF) family, FGF10, emanates from the prospective limb mesoderm to serve as an endogenous initiator for limb bud formation. Fgf10 expression in the prospective limb mesenchyme precedes Fgf8 expression in the nascent apical ectoderm. Ectopic application of FGF10 to the chick embryonic flank can induce Fgf8 expression in the adjacent ectoderm, resulting in the formation of an additional complete limb. Expression of Fgf10 persists in the mesenchyme of the established limb bud and appears to interact with Fgf8 in the apical ectoderm and Sonic hedgehog in the zone of polarizing activity. These results suggest that FGF10 is a key mesenchymal factor involved in the initial budding as well as the continuous outgrowth of vertebrate limbs.
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Cites
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Receptor Specificity of the Fibroblast Growth Factor Family
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Cited by
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Self-citationMolecular Models for Vertebrate Limb Development
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Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud
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WNT Signals Control FGF-Dependent Limb Initiation and AER Induction in the Chick Embryo
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Metadata
- Authors
- Ohuchi, H., Nakagawa, T., Yamamoto, A., Araga, A., Ohata, T., Ishimaru, Y., Yoshioka, H., Kuwana, T., Nohno, T., Yamasaki, M., Itoh, N., & Noji, S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-06-01
- Volume
- 124
- Issue
- 11
- Pages
- 2235-2244
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2099002558
- Cited by
- 549
- References
- 45
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. https://app.cochat.ai/papers/10.1242/dev.124.11.2235
- The paper
- Ohuchi, H., Nakagawa, T., Yamamoto, A., Araga, A., Ohata, T., Ishimaru, Y., Yoshioka, H., Kuwana, T., Nohno, T., Yamasaki, M., Itoh, N., & Noji, S. (1997). The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development. https://doi.org/10.1242/dev.124.11.2235
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
