The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
Abstract
Serrate-like genes encode transmembrane ligands to Notch receptors and control cell fate decisions during development. In this report, we analyse the regulation of the mouse Serrate-1 gene during embryogenesis. The Serrate-1 gene is expressed from embryonic day 7.5 (E7.5) and expression is often observed at sites of epithelial-mesenchymal interactions, including the developing tooth, where Serrate-1 is first (E11.5) expressed in all cells of the dental epithelium, but not in mesenchyme. A transient upregulation in dental mesenchyme (E12.5-15.5) is correlated with down-regulation of Serrate-1 expression in epithelial cells contacting the mesenchyme, i.e. in the cells destined to become ameloblasts. This expression pattern is reproduced in explants of dental epithelium and mesenchyme in vitro: epithelium induces Serrate-1 expression in mesenchyme, while epithelium in close proximity to this mesenchyme does not express detectable levels of Serrate-1 mRNA, suggesting that downregulation of Serrate-1 expression in preameloblasts is caused by mesenchyme-derived signals. Finally, regulation of Serrate-1 expression differs from that of Notch genes. The Serrate-1 gene is induced in dental mesenchyme by fibroblast growth factor-4, but not by bone morphogenetic proteins, while the converse is true for Notch genes. This indicates that, at least during tooth development, the expression patterns observed for receptors and ligands in the Notch signaling pathway are generated by different induction mechanisms.
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Cites
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1996) · Nature · doi:10.1038/383707a0 · Cited by 2,068
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Notch signalling controls pancreatic cell differentiation
Apelqvist, Å., Li, H., Sommer, L., Beatus, P., Anderson, D. J., Honjo, T., de Angelis, M. H., Lendahl, U., & Edlund, H. (1999) · Nature · doi:10.1038/23716 · Cited by 1,159
Self-citationControl of endodermal endocrine development by Hes-1
Jensen, J., Pedersen, E. E., Galante, P., Hald, J., Heller, R. S., Ishibashi, M., Kageyama, R., Guillemot, F., Serup, P., & Madsen, O. D. (2000) · Nature Genetics · doi:10.1038/71657 · Cited by 1,155
Harada, H., Kettunen, P., Jung, H.-S., Mustonen, T., Wang, Y. A., & Thesleff, I. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.105 · Cited by 517
Self-citationHenrique, D., Hirsinger, E., Adam, J., Roux, I. L., Pourquié, O., Ish-Horowicz, D., & Lewis, J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00293-4 · Cited by 431
Self-citationDefects in somite formation in lunatic fringe-deficient mice
Zhang, N., & Gridley, T. (1998) · Nature · doi:10.1038/28625 · Cited by 400
Notch Signaling in Vascular Development
Iso, T., Hamamori, Y., & Kedes, L. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000060892.81529.8f · Cited by 382
Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways
Shi, S., & Stanley, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831126100 · Cited by 381
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
Brooker, R., Hozumi, K., & Lewis, J. (2006) · Development · doi:10.1242/dev.02284 · Cited by 330
Making a tooth: growth factors, transcription factors, and stem cells
ZHANG, Y. D., CHEN, Z., SONG, Y. Q., LIU, C., & CHEN, Y. P. (2005) · Cell Research · doi:10.1038/sj.cr.7290299 · Cited by 313
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Metadata
- Authors
- Mitsiadis, T. A., Henrique, D., Thesleff, I., & Lendahl, U.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-04-15
- Volume
- 124
- Issue
- 8
- Pages
- 1473-1483
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2112121256
- Cited by
- 158
- References
- 1
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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