Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish
Abstract
Sonic hedgehog (Shh) is a secreted protein that is involved in the organization and patterning of several tissues in vertebrates. We show that the zebrafish sonic-you (syu) gene, a member of a group of five genes required for somite patterning, is encoding Shh. Embryos mutant for a deletion of syu display defects in patterning of the somites, the lateral floor plate cells, the pectoral fins, the axons of motorneurons and the retinal ganglion cells. In contrast to mouse embryos lacking Shh activity, syu mutant embryos do form medial floor plate cells and motorneurons. Since ectopic overexpression of shh in zebrafish embryos does not induce ectopic medial floor plate cells, we conclude that shh is neither required nor sufficient to induce this cell type in the zebrafish.
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In zebrafish, shh and signals from the AER orchestrate patterning and outgrowth of the early fin buds.
“In the zebrafish, shh and signals from the AER also orchestrate patterning and outgrowth of the early fin buds [28]–[30].”
From Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates (2008) · cites this paper as [29]
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Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581 · see citing works
A homeobox gene essential for zebrafish notochord development
Talbot, W. S., Trevarrow, B., Halpern, M. E., Melby, A. E., Farr, G., Postlethwait, J. H., Jowett, T., Kimmel, C. B., & Kimelman, D. (1995) · Nature · doi:10.1038/378150a0 · Cited by 465 · see citing works
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Harris, M. P., Rohner, N., Schwarz, H., Perathoner, S., Konstantinidis, P., & Nüsslein-Volhard, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000206 · Cited by 224 · see citing works
Zou, S., Kamei, H., Modi, Z., & Duan, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007026 · Cited by 122 · see citing works
Joksimovic, M., Anderegg, A., Roy, A., Campochiaro, L., Yun, B., Kittappa, R., McKay, R., & Awatramani, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904285106 · Cited by 121 · see citing works
- Authors
- Schauerte, H. E., Eeden, F. J. M. V., Fricke, C., Odenthal, J., Strähle, U., & Haffter, P.
- Affiliations
- Max Planck Institute for Developmental Biology (DE)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- Corresponding author
- Haffter, Pascal
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-08-01
- Volume
- 125
- Issue
- 15
- Pages
- 2983-2993
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2101024791
- Cited by
- 349
- References
- 2
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 6 · 2013: 5 · 2012: 9
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Keywords
- Sonic hedgehog, somite patterning, retinal ganglion cells, pectoral fin development, zebrafish mutants, cell induction
- MeSH terms
- PAX6 Transcription Factor, Animals, Axons, DNA-Binding Proteins, Embryonic Induction, Eye, Eye Proteins, Genetic Complementation Test, Muscles, Mutation, Nervous System, Nervous System Malformations, Proteins, Repressor Proteins, Retinal Ganglion Cells, RNA Splicing, Stem Cells, Transcription Factors, Zebrafish, Signal Transduction, Trans-Activators, Sequence Analysis, DNA, Cyclic AMP-Dependent Protein Kinases, Homeodomain Proteins, Somites, Body Patterning, Protein Sorting Signals, Zebrafish Proteins, Paired Box Transcription Factors, PAX2 Transcription Factor, Hedgehog Proteins
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