The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans
Abstract
C. elegans cki-1 encodes a member of the CIP/KIP family of cyclin-dependent kinase inhibitors, and functions to link postembryonic developmental programs to cell cycle progression. The expression pattern of cki-1::GFP suggests that cki-1 is developmentally regulated in blast cells coincident with G1, and in differentiating cells. Ectopic expression of CKI-1 can prematurely arrest cells in G1, while reducing cki-1 activity by RNA-mediated interference (RNAi) causes extra larval cell divisions, suggesting a role for cki-1 in the developmental control of G1/S. cki-1 activity is required for the suspension of cell cycling that occurs in dauer larvae and starved L1 larvae in response to environmental signals. In vulva precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 stage.
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Cites
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Self-citationHow Proteolysis Drives the Cell Cycle
King, R. W., Deshaies, R. J., Peters, J.-M., & Kirschner, M. W. (1996) · Science · doi:10.1126/science.274.5293.1652 · Cited by 1,273
Heterochronic Mutants of the Nematode Caenorhabditis elegans
Ambros, V., & Horvitz, H. R. (1984) · Science · doi:10.1126/science.6494891 · Cited by 797
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Cited by
Size Control in Animal Development
Conlon, I., & Raff, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80563-2 · Cited by 743
Regulation of miRNA expression during neural cell specification
Smirnova, L., Gräfe, A., Seiler, A., Schumacher, S., Nitsch, R., & Wulczyn, F. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03978.x · Cited by 707
C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress
Melentijevic, I., Toth, M. L., Arnold, M. L., Guasp, R. J., Harinath, G., Nguyen, K. C., Taub, D., Parker, J. A., Neri, C., Gabel, C. V., et al. (2017) · Nature · doi:10.1038/nature21362 · Cited by 454
McGhee, J. (2007) · WormBook · doi:10.1895/wormbook.1.133.1 · Cited by 324
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Metadata
- Authors
- Hong, Y., Roy, R., & Ambros, V.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-09-15
- Volume
- 125
- Issue
- 18
- Pages
- 3585-3597
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2112327312
- Cited by
- 204
- References
- 3
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans. https://app.cochat.ai/papers/10.1242/dev.125.18.3585
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- Hong, Y., Roy, R., & Ambros, V. (1998). Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans. Development. https://doi.org/10.1242/dev.125.18.3585
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