Heterochronic Mutants of the Nematode Caenorhabditis elegans
Abstract
Mutations in the Caenorhabditis elegans genes lin-14 , lin-28 , and lin-29 cause heterochronic developmental defects: the timing of specific developmental events in several tissues is altered relative to the timing of events in other tissues. These defects result from temporal transformations in the fates of specific cells, that is, certain cells express fates normally expressed by cells generated at other developmental stages. The identification and characterization of genes that can be mutated to cause heterochrony support the proposal that heterochrony is a mechanism for phylogenetic change and suggest cellular and genetic bases for heterochronic variation.
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Gene expression analysis of cortical tissue showed robust down-regulation of LIN28B during midfetal cortical development in DS.
“Evidence for heterochrony in DS is revealed by gene expression analysis of cortical tissue that showed the robust down-regulation during midfetal cortical development of LIN28B, a gene that promotes proliferation of NPCs in a developmental, stage-specific manner and is one of the genes mutated in the original heterochronic C. elegans mutants39,150,151.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [150]
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“during studies of the control of developmental timing [”
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Ong, K. K., Elks, C. E., Li, S., Zhao, J. H., Luan, J., Andersen, L. B., Bingham, S. A., Brage, S., Smith, G. D., Ekelund, U., et al. (2009) · Nature Genetics · doi:10.1038/ng.382 · Cited by 366 · see citing works
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Consequences of trisomy 21 for brain development in Down syndrome
Russo, M. L., Sousa, A. M. M., & Bhattacharyya, A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-024-00866-2 · Cited by 28 · see citing works
“…analysis of cortical tissue that showed the robust down-regulation during midfetal cortical development of LIN28B , a gene that promotes proliferation of NPCs in a developmental, stage-specific manner and is one of the genes mutated in the original heterochronic C. elegans mutants 39,150,151 .”
- Authors
- Ambros, V., & Horvitz, H. R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- Science
- Published
- 1984-10-26
- Volume
- 226
- Issue
- 4673
- Pages
- 409-416
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062376760
- Cited by
- 797
- References
- 0
- Citations by year
- 2026: 12 · 2025: 26 · 2024: 34 · 2023: 33 · 2022: 25 · 2021: 33 · 2020: 25 · 2019: 31 · 2018: 29 · 2017: 29 · 2016: 31 · 2015: 35 · 2014: 28 · 2013: 40 · 2012: 34
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- heterochrony, Caenorhabditis elegans, lin-14, Lin28, developmental timing, temporal transformation, cell fate specification
- MeSH terms
- Animals, Caenorhabditis, Female, Genes, Male, Mutation, Phylogeny, Time Factors, Genetic Variation
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