The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation
Abstract
A new conditional Egfr allele was used to dissect the roles of the receptor in eye development and to test two published models. EGFR function is necessary for morphogenetic furrow initiation, is not required for establishment of the founder R8 cell in each ommatidium, but is necessary to maintain its differentiated state. EGFR is required subsequently for recruitment of all other neuronal cells. The initial EGFR-dependent MAP kinase activation occurs in the furrow, but the active kinase (dp-ERK) is observed only in the cytoplasm for over 2 hours. Similarly, SEVENLESS-dependent activation results in cytoplasmic appearance of dp-ERK for 6 hours. These results suggest an additional regulated step in this pathway and we discuss models for this.
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Cites
Schweitzer, R., Shaharabany, M., Seger, R., & Shilo, B. Z. (1995) · Genes & Development · doi:10.1101/gad.9.12.1518 · Cited by 317
Self-citation
Cited by
EGF signaling regulates the proliferation of intestinal stem cells in Drosophila
Biteau, B., & Jasper, H. (2011) · Development · doi:10.1242/dev.056671 · Cited by 306
Li, X., & Carthew, R. W. (2005) · Cell · doi:10.1016/j.cell.2005.10.040 · Cited by 304
Building an ommatidium one cell at a time
Kumar, J. P. (2012) · Developmental Dynamics · doi:10.1002/dvdy.23707 · Cited by 170
Self-citationActivation of EGF Receptor Kinase by L1-mediated Homophilic Cell Interactions
Islam, R., Kristiansen, L. V., Romani, S., Garcia-Alonso, L., & Hortsch, M. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-05-0333 · Cited by 83
Metadata
- Authors
- Kumar, J. P., Tio, M., Hsiung, F., Akopyan, S., Gabay, L., Seger, R., Shilo, B.-Z., & Moses, K.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-10-01
- Volume
- 125
- Issue
- 19
- Pages
- 3875-3885
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2122813534
- Cited by
- 169
- References
- 1
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
