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Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila
Abstract
In Drosophila wing discs, a morphogen gradient of DPP has been proposed to determine the transcriptional response thresholds of the downstream genes sal and omb. We present evidence that the concentration of the type I receptor TKV must be low to allow long-range DPP diffusion. Low TKV receptor concentrations result, however, in low signaling activity. To enhance signaling at low DPP concentrations, we find that a second ligand, GBB, augments DPP/TKV activity. GBB signals primarily through the type I receptor SAX, which synergistically enhances TKV signaling and is required for proper OMB expression. We show that OMB expression in wing discs requires synergistic signaling by multiple ligands and receptors to overcome the limitations imposed on DPP morphogen function by receptor concentration levels.
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Citations
Cited by
Dpp Gradient Formation in the Drosophila Wing Imaginal Disc
Teleman, A. A., & Cohen, S. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00199-9 · Cited by 454
Song, X., Wong, M. D., Kawase, E., Xi, R., Ding, B. C., McCarthy, J. J., & Xie, T. (2004) · Development · doi:10.1242/dev.01026 · Cited by 416
McCabe, B. D., Marqués, G., Haghighi, A. P., Fetter, R. D., Crotty, M. L., Haerry, T. E., Goodman, C. S., & O'Connor, M. B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00426-4 · Cited by 388
Self-citationTGF-β Family Signal Transduction in Drosophila Development: From Mad to Smads
Raftery, L. A., & Sutherland, D. J. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9282 · Cited by 321
Twisted gastrulation is a conserved extracellular BMP antagonist
Ross, J. J., Shimmi, O., Vilmos, P., Petryk, A., Kim, H., Gaudenz, K., Hermanson, S., Ekker, S. C., O'Connor, M. B., & Marsh, J. L. (2001) · Nature · doi:10.1038/35068578 · Cited by 302
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Metadata
- Authors
- Haerry, T. E., Khalsa, O., O'Connor, M. B., & Wharton, K. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-10-15
- Volume
- 125
- Issue
- 20
- Pages
- 3977-3987
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2183101699
- Cited by
- 217
- References
- 0
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haerry, T. E., Khalsa, O., O'Connor, M. B., & Wharton, K. A. (1998). Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila. Development. https://doi.org/10.1242/dev.125.20.3977
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
