The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Dpp Gradient Formation in the Drosophila Wing Imaginal Disc
Open accessAbstract
The secreted signaling protein Dpp acts as a morphogen to pattern the anterior-posterior axis of the Drosophila wing. Dpp activity is required in all cells of the developing wing imaginal disc, but the ligand gradient that supports this activity has not been characterized. Here we make use of a biologically active form of Dpp tagged with GFP to examine the ligand gradient. Dpp-GFP forms an unstable extracellular gradient that spreads rapidly in the wing disc. The activity gradient visualized by MAD phosphorylation differs in shape from the ligand gradient. The pMAD gradient adjusted to compartment size when this was experimentally altered. These observations suggest that the Dpp activity gradient may be shaped at the level of receptor activation.
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Self-citation
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Lin, X. (2004) · Development · doi:10.1242/dev.01522 · Cited by 678
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Ashe, H. L., & Briscoe, J. (2006) · Development · doi:10.1242/dev.02238 · Cited by 486
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Do Morphogen Gradients Arise by Diffusion?
Lander, A. D., Nie, Q., & Wan, F. Y. M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00179-x · Cited by 406
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Forgacs, G., & Newman, S. A. (2005) · doi:10.1017/cbo9780511755576 · Cited by 339
Metadata
- Authors
- Teleman, A. A., & Cohen, S. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 103
- Issue
- 6
- Pages
- 971-980
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2113695281
- Cited by
- 454
- References
- 37
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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