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Cited by 346

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections

Bagnard, Dominique, Lohrum, Marion, Uziel, Daniela, Püschel, Andreas W., Bolz, Jürgen·1998·Development
DOI 10.1242/dev.125.24.5043
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Abstract

Members of the semaphorin family have been implicated in mediating axonal guidance in the nervous system by their ability to collapse growth cones and to function as chemorepellents. The present findings show that recombinant Semaphorin D has similar effects on cortical axons and, in addition, inhibits axonal branching. In contrast, semaphorin E acts as an attractive guidance signal for cortical axons. Attractive effects were only observed when growth cones encountered increasing concentrations or a patterned distribution of Semaphorin E, but not when they are exposed to uniform concentrations of this molecule. Specific binding sites for Semaphorin D and Semaphorin E were present on cortical fibers both in vitro and in vivo at the time when corticofugal projections are established. In situ hybridization analysis revealed that the population of cortical neurons used in our experiments express neuropilin-1 and neuropilin-2, which are essential components of receptors for the class III semaphorins. Moreover, semD mRNA was detected in the ventricular zone of the neocortex whereas semE mRNA was restricted to the subventricular zone. Taken together, these results indicate that semaphorins are bifunctional molecules whose effects depend on their spatial distribution. The coordinated expression of different semaphorins, together with their specific activities on cortical axons, suggests that multiple guidance signals contribute to the formation of precise corticofugal pathways.

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Metadata

Authors
Bagnard, D., Lohrum, M., Uziel, D., Püschel, A. W., & Bolz, J.
Venue
Development
Publisher
The Company of Biologists
Published
1998-12-15
Volume
125
Issue
24
Pages
5043-5053
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.125.24.5043
OpenAlex
W2135255676
Cited by
346
References
58
FWCI
9.13
Type
journal article
Language
en
Open access
closed

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