Semaphorin Regulation of Cellular Morphology
Abstract
Semaphorin proteins, although initially characterized as repulsive neuronal guidance cues, are now appreciated as major contributors to morphogenesis and homeostasis for a wide range of tissue types. Semaphorin-mediated long- and short-range repulsive, and attractive, guidance has profound influences on cellular morphology. The diversity of semaphorin receptor complexes utilized by various semaphorin ligands, the ability of semaphorins themselves to serve as receptors, and the myriad of intracellular signaling components that comprise semaphorin signaling cascades all contribute to cell-type-specific responses to semaphorins. Analysis of the molecular and cellular mechanisms underlying semaphorin function in neural and vascular systems provides insight into principles governing how this large protein family contributes to organogenesis, function, and disease.
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Plexin-B1 is a member of the plexin axon guidance receptor family.
“Plexin-B1 is a member of the plexin axon guidance receptor family14.”
From Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease (2024) · cites this paper as [14]
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“Plexin-B1 is an axon guidance receptor of the plexin family 14 .”
- Authors
- Tran, T. S., Kolodkin, A. L., & Bharadwaj, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2007-11-01
- Volume
- 23
- Issue
- 1
- Pages
- 263-292
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2131860275
- Cited by
- 388
- References
- 2
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 11 · 2023: 14 · 2022: 8 · 2021: 19 · 2020: 19 · 2019: 17 · 2018: 12 · 2017: 18 · 2016: 23 · 2015: 26 · 2014: 30 · 2013: 31 · 2012: 38
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Johns Hopkins University
- National Institutes of Health
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- semaphorins, cell morphology, morphogenesis, semaphorin receptors, semaphorin signaling, tissue homeostasis, organogenesis, neural development, vascular development
- MeSH terms
- Animals, Cell Movement, Heart, Humans, Neurons, Receptors, Cell Surface, Signal Transduction, Organogenesis, Semaphorins
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