The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
NeuroD regulates multiple functions in the developing neural retina in rodent
Abstract
The expression and function of the basic helix-loop-helix (bHLH) transcription factor NeuroD were studied in the developing neural retina in rodent. neuroD was expressed in areas of undetermined retinal cells as well as developing photoreceptors and amacrine interneurons. Expression was maintained in a subset of mature photoreceptors in the adult retina. Using both loss-of-function and gain-of-function approaches, NeuroD was found to play multiple roles in retinal development. (1) NeuroD was found to be a critical regulator of the neuron versus glial cell fate decision. Retinal explants derived from NeuroD-null mice demonstrated a three-to fourfold increase in Müller glia. Forced expression of neuroD in progenitors in rat using retroviruses hastened cell cycle withdrawal and blocked gliogenesis in vivo. (2) NeuroD appeared to regulate interneuron development, favouring amacrine over bipolar differentiation. Forced NeuroD expression resulted in an increase in amacrine interneurons and a decrease in bipolar interneurons. In the complementary experiment, retinae derived from NeuroD-null mice demonstrated a twofold increase in bipolar interneurons and a delay in amacrine differentiation. (3) NeuroD appeared to be essential for the survival of a subset of rod photoreceptors. In conclusion, these results implicate NeuroD in a variety of developmental functions including cell fate determination, differentiation and neuron survival.
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Citations
Cites
The MyoD family and myogenesis: Redundancy, networks, and thresholds
Weintraub, H. (1993) · Cell · doi:10.1016/0092-8674(93)90610-3 · Cited by 1,057
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Bylund, M., Andersson, E., Novitch, B. G., & Muhr, J. (2003) · Nature Neuroscience · doi:10.1038/nn1131 · Cited by 825
Novitch, B. G., Chen, A. I., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00407-x · Cited by 615
Fode, C., Ma, Q., Casarosa, S., Ang, S.-L., Anderson, D. J., & Guillemot, F. (2000) · Genes & Development · doi:10.1101/gad.14.1.67 · Cited by 624
Ma, Q., Fode, C., Guillemot, F., & Anderson, D. J. (1999) · Genes & Development · doi:10.1101/gad.13.13.1717 · Cited by 508
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina
Ooto, S., Akagi, T., Kageyama, R., Akita, J., Mandai, M., Honda, Y., & Takahashi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402129101 · Cited by 454
Metadata
- Authors
- Morrow, E. M., Furukawa, T., Lee, J. E., & Cepko, C. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-01-01
- Volume
- 126
- Issue
- 1
- Pages
- 23-36
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2147635933
- Cited by
- 360
- References
- 1
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Morrow, E. M., Furukawa, T., Lee, J. E., & Cepko, C. L. (1999). NeuroD regulates multiple functions in the developing neural retina in rodent. Development. https://doi.org/10.1242/dev.126.1.23
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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