Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
Open accessAbstract
Within the developing vertebrate nervous system, the mechanisms that coordinate neuronal subtype identity with generic features of neuronal differentiation are poorly defined. We show here that a bHLH protein, Olig2, is expressed selectively by motor neuron progenitors and has a key role in specifying the subtype identity and pan-neuronal properties of developing motor neurons. The role of Olig2 in the specification of motor neuron subtype identity depends on regulatory interactions with progenitor homeodomain proteins, whereas its role in promoting pan-neuronal properties is associated with expression of another bHLH protein, Ngn2. Both aspects of Olig2 function appear to depend on its activity as a transcriptional repressor. Together, these studies show that Olig2 has a critical role in integrating diverse features of motor neuron differentiation in the developing spinal cord.
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The prominence of motor neurons at early stages is consistent with the initially high differentiation rate of MN progenitors.
“which is consistent with the initially high differentiation rate of MN progenitors”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Novitch et al., 2001
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- Authors
- Novitch, B. G., Chen, A. I., & Jessell, T. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jessell, Thomas M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 31
- Issue
- 5
- Pages
- 773-789
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2082807347
- Cited by
- 615
- References
- 58
- Citations by year
- 2026: 14 · 2025: 9 · 2024: 16 · 2023: 10 · 2022: 20 · 2021: 13 · 2020: 19 · 2019: 17 · 2018: 15 · 2017: 15 · 2016: 20 · 2015: 26 · 2014: 40 · 2013: 20 · 2012: 35
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Damon Runyon Cancer Research Foundation (DRG-1569)
- National Institutes of Health (5T32GM08224)
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- Olig2, motor neurons, Ngn2, homeodomain transcription factor, motor neuron progenitors, neuronal differentiation, spinal cord development, transcriptional repression
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Cell Cycle, Cell Differentiation, Central Nervous System, Chick Embryo, Fetus, Immunohistochemistry, Molecular Sequence Data, Motor Neurons, Nerve Tissue Proteins, Repressor Proteins, Stem Cells, Transcription Factors, Transcription, Genetic, In Situ Hybridization, Protein Structure, Tertiary, Helix-Loop-Helix Motifs, Homeodomain Proteins, Gene Expression Regulation, Developmental, Body Patterning, Mice, Basic Helix-Loop-Helix Proteins
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