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Cited by 317

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Role of vascular endothelial-cadherin in vascular morphogenesis

Gory-Fauré, Sylvie, Prandini, Marie-Hélène, Pointu, Hervé, Roullot, Valérie, Pignot-Paintrand, Isabelle, Vernet, Muriel, Huber, Philippe·1999·Development
DOI 10.1242/dev.126.10.2093
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Abstract

Vascular endothelial (VE)-cadherin is an adhesive transmembrane protein specifically expressed at interendothelial junctions. Its extracellular domain exhibits Ca2+-dependent homophilic reactivity, promoting cell-cell recognition. Mice deficient in VE-cadherin die at mid-gestation resulting from severe vascular defects. At the early phases of vascular development (E8.5) of VE- cadherin-deficient embryos, in situ differentiation of endothelial cells was delayed although their differentiation program appeared normal. Vascularization was defective in the anterior part of the embryo, while dorsal aortae and vitelline and umbilical arteries formed normally in the caudal part. At E9.25, organization of endothelial cells into large vessels was incomplete and angiogenesis was impaired in mutant embryos. Defects were more severe in extraembryonic vasculature. Blood islands of the yolk sac and clusters of angioblasts in allantois failed to establish a capillary plexus and remained isolated. This was not due to defective cell-cell recognition as endothelial cells formed intercellular junctions, as shown by electron microscopy. These data indicate that VE-cadherin is dispensable for endothelial homophilic adhesion but is required for vascular morphogenesis.

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Metadata

Authors
Gory-Fauré, S., Prandini, M.-H., Pointu, H., Roullot, V., Pignot-Paintrand, I., Vernet, M., & Huber, P.
Venue
Development
Publisher
The Company of Biologists
Published
1999-05-15
Volume
126
Issue
10
Pages
2093-2102
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.126.10.2093
OpenAlex
W2110372792
Cited by
317
References
52
FWCI
4.02
Type
journal article
Language
en
Open access
closed

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