The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Sonic hedgehog regulates the growth and patterning of the cerebellum
Abstract
The molecular bases of brain development and CNS malignancies remain poorly understood. Here we show that Sonic hedgehog (Shh) signaling controls the development of the cerebellum at multiple levels. SHH is produced by Purkinje neurons, it is required for the proliferation of granule neuron precursors and it induces the differentiation of Bergmann glia. Blocking SHH function in vivo results in deficient granule neuron and Bergmann glia differentiation as well as in abnormal Purkinje neuron development. Thus, our findings provide a molecular model for the growth and patterning of the cerebellum by SHH through the coordination of the development of cortical cerebellar cell types. In addition, they provide a cellular context for medulloblastomas, childhood cancers of the cerebellum.
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Cites
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science · doi:10.1126/science.280.5369.1603 · Cited by 848
Curran, T., & D'Arcangelo, G. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00035-0 · Cited by 246
Cited by
Hedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
Watkins, D. N., Berman, D. M., Burkholder, S. G., Wang, B., Beachy, P. A., & Baylin, S. B. (2003) · Nature · doi:10.1038/nature01493 · Cited by 1,082
Clement, V., Sanchez, P., de Tribolet, N., Radovanovic, I., & Ruiz i Altaba, A. (2007) · Current Biology · doi:10.1016/j.cub.2006.11.033 · Cited by 1,050
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches
Machold, R., Hayashi, S., Rutlin, M., Muzumdar, M. D., Nery, S., Corbin, J. G., Gritli-Linde, A., Dellovade, T., Porter, J. A., Rubin, L. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00561-0 · Cited by 710
Metadata
- Authors
- Dahmane, N., & Altaba, A. R. I.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-07-15
- Volume
- 126
- Issue
- 14
- Pages
- 3089-3100
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2117492061
- Cited by
- 907
- References
- 3
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dahmane, N., & Altaba, A. R. I. (1999). Sonic hedgehog regulates the growth and patterning of the cerebellum. Development. https://doi.org/10.1242/dev.126.14.3089
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
