The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The DNA-binding Polycomb group protein Pleiohomeotic mediates silencing of a Drosophila homeotic gene
Abstract
SUMMARY: Polycomb group (PcG) proteins repress homeotic genes in cells where these genes must remain inactive during development. This repression requires cis-acting silencers, also called PcG response elements. Currently, these silencers are ill-defined sequences and it is not known how PcG proteins associate with DNA. Here, we show that the Drosophila PcG protein Pleiohomeotic binds to specific sites in a silencer of the homeotic gene Ultrabithorax. In an Ultrabithorax reporter gene, point mutations in these Pleiohomeotic binding sites abolish PcG repression in vivo. Hence, DNA-bound Pleiohomeotic protein may function in the recruitment of other non-DNA-binding PcG proteins to homeotic gene silencers.
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Citations
Cites
Segmental distribution of bithorax complex proteins during Drosophila development
Beachy, P. A., Helfand, S. L., & Hogness, D. S. (1985) · Nature · doi:10.1038/313545a0 · Cited by 413
Simon, J., Peifer, M., Bender, W., & O'Connor, M. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07615.x · Cited by 159
Cited by
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775
Histone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241
Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins
Ringrose, L., & Paro, R. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.091907 · Cited by 1,077
Polycomb silencing mechanisms and the management of genomic programmes
Schwartz, Y. B., & Pirrotta, V. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1981 · Cited by 868
Hierarchical Recruitment of Polycomb Group Silencing Complexes
Wang, L., Brown, J. L., Cao, R., Zhang, Y., Kassis, J. A., & Jones, R. S. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.009 · Cited by 561
Self-citation
Metadata
- Authors
- Fritsch, C., Lesley Brown, J., Kassis, J. A., & Müller, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-09-01
- Volume
- 126
- Issue
- 17
- Pages
- 3905-3913
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1820935146
- Cited by
- 185
- References
- 2
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
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