The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription
Abstract
Heart formation in Drosophila is dependent on the homeobox gene tinman. The homeobox gene Nkx2-5 is closely related to tinman and is the earliest known marker for cardiogenesis in vertebrate embryos. Recent studies of cis-regulatory elements required for Nkx2-5 expression in the developing mouse heart have revealed an extraordinary array of independent cardiac enhancers, and associated negative regulatory elements, that direct transcription in distinct regions of the embryonic heart. These studies demonstrate the modularity in cardiac transcription, in which different regulatory elements respond to distinct sets of transcription factors to control gene expression in different compartments of the developing heart. We consider the potential mechanisms underlying such transcriptional complexity, its possible significance for cardiac function, and the implications for evolution of the multichambered heart.
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Cites
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B., & Evans, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31636-8 · Cited by 558
Chen, C. Y., & Schwartz, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15628 · Cited by 287
Self-citation
Cited by
Gene Regulatory Networks in the Evolution and Development of the Heart
Olson, E. N. (2006) · Science · doi:10.1126/science.1132292 · Cited by 1,015
Self-citationThe Arterial Pole of the Mouse Heart Forms from Fgf10-Expressing Cells in Pharyngeal Mesoderm
Kelly, R. G., Brown, N. A., & Buckingham, M. E. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00040-5 · Cited by 853
A genetic blueprint for cardiac development
Srivastava, D., & Olson, E. N. (2000) · Nature · doi:10.1038/35025190 · Cited by 631
Self-citationVerzi, M. P., McCulley, D. J., De Val, S., Dodou, E., & Black, B. L. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.041 · Cited by 527
Patterning the vertebrate heart
Harvey, R. P. (2002) · Nature Reviews Genetics · doi:10.1038/nrg843 · Cited by 450
Metadata
- Authors
- Schwartz, R. J., & Olson, E. N.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-10-01
- Volume
- 126
- Issue
- 19
- Pages
- 4187-4192
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2114748673
- Cited by
- 185
- References
- 2
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schwartz, R. J., & Olson, E. N. (1999). Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription. Development. https://doi.org/10.1242/dev.126.19.4187
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
