The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline
Open accessAbstract
Development of the nematode Caenorhabditis elegans is highly reproducible and the fate of every somatic cell has been reported. We describe here a previously uncharacterized cell fate in C. elegans: we show that germ cells, which in hermaphrodites can differentiate into sperm and oocytes, also undergo apoptotic cell death. In adult hermaphrodites, over 300 germ cells die, using the same apoptotic execution machinery (ced-3, ced-4 and ced-9) as the previously described 131 somatic cell deaths. However, this machinery is activated by a distinct pathway, as loss of egl-1 function, which inhibits somatic cell death, does not affect germ cell apoptosis. Germ cell death requires ras/MAPK pathway activation and is used to maintain germline homeostasis. We suggest that apoptosis eliminates excess germ cells that acted as nurse cells to provide cytoplasmic components to maturing oocytes.
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Cites
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Genetic control of programmed cell death in the nematode C. elegans
Ellis, H. (1986) · Cell · doi:10.1016/0092-8674(86)90004-8 · Cited by 1,828
Cited by
(2001) · PubMed · Cited by 2,381
Garigan, D., Hsu, A.-L., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Genetics · doi:10.1093/genetics/161.3.1101 · Cited by 803
Martinez, J., Almendinger, J., Oberst, A., Ness, R., Dillon, C. P., Fitzgerald, P., Hengartner, M. O., & Green, D. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113421108 · Cited by 655
Self-citationRetractedCED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
Zhou, Z., Hartwieg, E., & Horvitz, H. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00190-8 · Cited by 600
Self-citationBH3-only proteins in apoptosis and beyond: an overview
Lomonosova, E., & Chinnadurai, G. (2008) · Oncogene · doi:10.1038/onc.2009.39 · Cited by 458
Metadata
- Authors
- Gumienny, T. L., Lambie, E., Hartwieg, E., Horvitz, H. R., & Hengartner, M. O.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-03-01
- Volume
- 126
- Issue
- 5
- Pages
- 1011-1022
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2127244622
- Cited by
- 671
- References
- 2
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
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