The DOI matches its Crossref record.
The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping
Abstract
Left-right asymmetry in vertebrates is controlled by activities emanating from the left lateral plate. How these signals get transmitted to the forming organs is not known. A candidate mediator in mouse, frog and zebrafish embryos is the homeobox gene Pitx2. It is asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube. Localized Pitx2 expression continues when these organs undergo asymmetric looping morphogenesis. Ectopic expression of Xnr1 in the right lateral plate induces Pitx2 transcription in Xenopus. Misexpression of Pitx2 affects situs and morphology of organs. These experiments suggest a role for Pitx2 in promoting looping of the linear heart and gut.
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Citations
Cited by
Establishment of vertebrate left–right asymmetry
Hamada, H., Meno, C., Watanabe, D., & Saijoh, Y. (2002) · Nature Reviews Genetics · doi:10.1038/nrg732 · Cited by 489
Parallel genetic origins of pelvic reduction in vertebrates
Shapiro, M. D., Bell, M. A., & Kingsley, D. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604706103 · Cited by 216
Currie, K. W., & Pearson, B. J. (2013) · Development · doi:10.1242/dev.098590 · Cited by 131
Poulain, M., & Lepage, T. (2002) · Development · doi:10.1242/dev.129.21.4901 · Cited by 96
Metadata
- Authors
- Campione, M., Steinbeisser, H., Schweickert, A., Deissler, K., Bebber, F. V., Lowe, L. A., Nowotschin, S., Viebahn, C., Haffter, P., Kuehn, M. R., & Blum, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-03-15
- Volume
- 126
- Issue
- 6
- Pages
- 1225-1234
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2102105685
- Cited by
- 343
- References
- 0
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. https://app.cochat.ai/papers/10.1242/dev.126.6.1225
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- Campione, M., Steinbeisser, H., Schweickert, A., Deissler, K., Bebber, F. V., Lowe, L. A., Nowotschin, S., Viebahn, C., Haffter, P., Kuehn, M. R., & Blum, M. (1999). The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. Development. https://doi.org/10.1242/dev.126.6.1225
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
