The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tbx5 is essential for heart development
Abstract
Mutations in the Tbx5 transcription factor cause heart septal defects found in human Holt-Oram Syndrome. The complete extent to which Tbx5 functions in heart development, however, has not been established. Here we show that, in Xenopus embryos, Tbx5 is expressed in the early heart field, posterior to the cardiac homeobox transcription factor, Nkx2.5. During morphogenesis, Tbx5 is expressed throughout the heart tube except the anterior portion, the bulbus cordis. When Tbx5 activity is antagonized with a hormone-inducible, dominant negative version of the protein, the heart fails to develop. These results suggest that, in addition to its function in heart septation, Tbx5 has a more global role in cardiac specification and heart development in vertebrate embryos.
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Cites
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B., & Evans, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31636-8 · Cited by 558
Cited by
Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex
Foley, A. C., & Mercola, M. (2005) · Genes & Development · doi:10.1101/gad.1279405 · Cited by 195
Reptilian heart development and the molecular basis of cardiac chamber evolution
Koshiba-Takeuchi, K., Mori, A. D., Kaynak, B. L., Cebra-Thomas, J., Sukonnik, T., Georges, R. O., Latham, S., Beck, L., Henkelman, R. M., Black, B. L., et al. (2009) · Nature · doi:10.1038/nature08324 · Cited by 182
Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome
Ghosh, T. K. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.18.1983 · Cited by 150
Coll, M., Seidman, J. G., & Müller, C. W. (2002) · Structure · doi:10.1016/s0969-2126(02)00722-0 · Cited by 121
He, M.-L., Wen, L., Campbell, C. E., Wu, J. Y., & Rao, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10212 · Cited by 120
Metadata
- Authors
- Horb, M. E., & Thomsen, G. H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-04-15
- Volume
- 126
- Issue
- 8
- Pages
- 1739-1751
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2162614739
- Cited by
- 218
- References
- 1
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Horb, M. E., & Thomsen, G. H. (1999). Tbx5 is essential for heart development. Development. https://doi.org/10.1242/dev.126.8.1739
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
